Chongqing Jiulongpo People's Hospital

Impaired amyloid-beta uptake and distinct transcriptomic profiles of monocytes in APOE4 carriers: The Chongqing Ageing and Dementia Study

The ε4 allele of the apolipoprotein E gene (APOE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). However, its impact on monocyte-mediated amyloid-β (Aβ) clearance and associated immune dysfunction remains poorly understood. Through Aβ uptake assays i...

Deep learning-powered virtual eosin-based elastic fiber framework imaging improves objective grading and prognostic stratification of lung adenocarcinoma

Histological grading of lung adenocarcinoma is limited by interobserver variability, particularly when distinguishing noninvasive lepidic growth from invasive patterns. This distinction depends on evaluation of the alveolar elastic fiber framework, which is often insufficiently v...