Institution
Chongqing Cancer Hospital
Recent research
- BiologyOpen access
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer‐related mortality. Integrative multi‐omics and machine‐learning analyses across independent cohorts identified CYYR1 as a frequently downregulated transmembrane protein in LUAD, with low expression associated w...
- Health & Medicine
ABSTRACT Background Although MR cytometry can probe microstructural features, the longitudinal trajectories of these changes during neoadjuvant chemotherapy (NAC) and their association with treatment response and prognosis remain poorly defined. Purpose To characterize longitudin...
- BiologyOpen access
Abstract Proteasome inhibitors have transformed cancer therapy in certain settings. However, their overall effectiveness is often limited as residual proteasome function is retained through the overexpression of ubiquitin-specific protease 14 (USP14), a proteasome-associated deub...
- BiologyOpen access
Abstract Background and purpose Head and neck squamous cell carcinoma (HNSCC) exhibits heterogeneous responses to radiotherapy; however, the underlying multi‐omics regulatory networks remain poorly characterized. This study elucidated the distinct post‐translational modification...
- Health & MedicineOpen access
The WHO 90-70-90 cervical cancer elimination targets require that 90% of women with screen-detected lesions receive appropriate treatment by 2030. Achieving this target depends on closing cascade gaps from screen-positive to diagnostic resolution. Whether intervention effectivene...
- Health & MedicineOpen access
Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer
IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...
- Health & MedicineOpen access
The role of neutrophil elastase (NE) in liver fibrosis caused by chronic hepatitis B (CHB) has not been fully clarified. This study sought to measure serum NE concentrations in individuals with CHB and to determine whether NE could serve as a noninvasive indicator for assessing C...
- BiologyOpen access
Abstract Purpose The radiation‐induced bystander effect (RIBE) refers to biological responses in non‐irradiated cells exposed to signals from irradiated cells and may contribute to tumor control during radiotherapy. Periodic dose heterogeneity caused by the thread effect of helic...
- Health & MedicineOpen access
A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...
- Health & MedicineOpen access
CACA guidelines for the management of adult cancer pain
Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...
- Health & MedicineOpen access
Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...
- Health & MedicineOpen access
Thyroid carcinoma is common, but the synchronous occurrence of bilateral tumors with discordant histology—specifically follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC)—is extremely rare. It is even more uncommon for such cases to present initially with dis...
- Health & MedicineOpen access
Acquired resistance limits durable control with crizotinib in metastatic ALK-positive non–small cell lung cancer (NSCLC). We characterized residual disease and initial progression patterns and identified predictors of candidates for consolidative stereotactic body radiation thera...