Institution
Chongqing Cancer Hospital
Recent research
- BiologyOpen access
Abstract Purpose The radiation‐induced bystander effect (RIBE) refers to biological responses in non‐irradiated cells exposed to signals from irradiated cells and may contribute to tumor control during radiotherapy. Periodic dose heterogeneity caused by the thread effect of helic...
- Health & MedicineOpen access
A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...
- Health & MedicineOpen access
CACA guidelines for the management of adult cancer pain
Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...
- Health & MedicineOpen access
Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...
- Health & MedicineOpen access
Thyroid carcinoma is common, but the synchronous occurrence of bilateral tumors with discordant histology—specifically follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC)—is extremely rare. It is even more uncommon for such cases to present initially with dis...
- Health & MedicineOpen access
Acquired resistance limits durable control with crizotinib in metastatic ALK-positive non–small cell lung cancer (NSCLC). We characterized residual disease and initial progression patterns and identified predictors of candidates for consolidative stereotactic body radiation thera...