Chonburi Hospital

High tacrolimus intrapatient variability is associated with graft loss after kidney transplantation: a systematic review and meta-analysis

Tacrolimus intrapatient variability (IPV) has been proposed as a predictor of adverse outcomes after kidney transplantation, but the magnitude and consistency of this association across IPV measurement methods remain unclear. We conducted a systematic review and meta-analysis of...

Anti-proliferative and anti-inflammatory potential of 2-chloro-3-((4-hydroxyphenyl)amino)naphthalene-1,4-dione through targeting TNF-α/IL-8 and NF-κB signaling in HCT116 cancer cells: a comprehensive in silico docking and in vitro study

Colorectal cancer (CRC) is closely associated with chronic inflammation, and the NF-κB pathway acts as a central regulator of the inflammatory response that promotes tumor progression. In this study, we examined the anticancer and anti-inflammatory potential of anilino-1,4-naphth...

Outcome of Targeted Therapy for Obstructive Sleep Apnea in Children with Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Background: Obstructive sleep apnea (OSA) and metabolic dysfunction-associated steatotic liver disease (MASLD) frequently coexist in children with obesity, but data on hepatic outcomes following OSA treatment are limited. This study evaluated associations between targeted OSA tre...