Chinese Institute for Brain Research

Encoding paremias as sets of proverbial markers: a computational study on Petronius’ Cena Trimalchionis

Abstract The goal of this work is to analyse the paremias contained in Petronius’ Cena Trimalchionis (CT) through qualitative, quantitative, and computational points of view to identify measures of their degree of proverbiality. We explore a typology of proverbial markers, includ...

MIMAS: An open-source microlens-array miniature microscope for accessible large-field cortical imaging in freely behaving mice

Large-scale cortical dynamics during natural behavior are difficult to measure because head-mounted imaging systems must balance field of view, spatial resolution, weight, and optical complexity. Existing wide-field miniature microscopes often rely on compound or custom-corrected...

Intrinsic functional architecture predicts remote motor cortical excitability changes induced by intermittent theta-burst stimulation

Repetitive transcranial magnetic stimulation (rTMS) modulates cortical excitability both locally and remotely through connected regions. However, how intrinsic functional architecture influences these remote effects remains unclear. Leveraging multi-site stimulation (targeting th...

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully...

ACC-projecting claustral neurons are required during cue pre-exposure for latent inhibition

In a noisy world, learning to ignore stimuli that repeatedly occur without consequence is essential for adaptive behavior. Latent inhibition, in which prior inconsequential cue exposure slows subsequent associative learning, captures this capacity. The claustrum is densely interc...

From endovascular therapy to perivascular therapy: A new concept and perspective

The cardiovascular system relies on an organ-spanning vascular network not only for transport but also for systemic homeostatic control. Surrounding the vessel wall is a complex perivascular microenvironment, including the vasa vasorum, autonomic and sensory nerves, perivascular...

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and a...

Perioperative non-invasive neuromodulation for delirium and cognitive recovery: from preclinical evidence to clinical translation

Perioperative neurocognitive disorders (PND) are a challenge for patients to accelerate postoperative recovery, and exploring more effective interventions can help reduce long-term cognitive dysfunction. Non-invasive neuromodulation (NIN) has shown potential in improving postoper...

Transdiagnostic latent factors dissociating depression and anxiety through reinforcement learning

The comorbidity of depression and anxiety has long been recognized. While mainly characterized as mood dysregulation, depression and anxiety symptoms are also manifested in learning and decision-making deficits. However, the specific cognitive mechanisms that are common to both d...

Deep Learning-Guided Identification and In Vivo Validation of Compact Cis-Regulatory Elements for the Zebrafish Habenula

Background/Objectives: Precise genetic access to the zebrafish habenula remains limited by a scarcity of compact, sequence-defined cis-regulatory elements (CREs). Here, we integrated developmental expression mapping, deep-learning predictions on long-range sequences, and in vivo...

Development of an explainable machine learning model for predicting six-month consciousness recovery in patients with prolonged disorders of consciousness

With advances in emergency care systems, the number of patients with prolonged disorders of consciousness (pDoC) has markedly increased. To optimize the allocation of healthcare resources and mitigate risks, the early and accurate identification of recovery potential in pDoC is e...

Nighttime Sensory–Behavioral Activation and Admission Suicidality in Young Inpatients With Major Depressive Disorder: A Retrospective Clinical‐Record Study

INTRODUCTION: Suicide risk assessment during psychiatric admission may benefit from clinically observable information beyond overall depressive symptom severity. This study examined whether clinician-documented nighttime sensory-behavioral activation was associated with admission...

Ticagrelor-Aspirin With Thrombolysis by Infarct Patterns in Moderate Ischemic Stroke: TAPIS Subgroup Analysis

BACKGROUND: Whether diffusion‑weighted imaging infarction patterns influence the efficacy and safety of early oral ticagrelor‑aspirin with intravenous thrombolysis in moderate acute ischemic stroke is uncertain. We assessed treatment effects by infarction pattern in this thrombol...

An Essential Role of the AMPK-Related Kinase Snrk in Regulating Drosophila Sleep

Abstract Protein kinases are important regulators of sleep in animals, but their loss-of-function mutations usually show moderate phenotypes. We report here that sucrose non-fermenting related kinase (Snrk), a member of the AMP-activated protein kinase-related kinase (ARK) family...

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...

Economic and social modulations of innate decision-making in mice exposed to visual threats

When confronted by predators, animals make innate decisions with rapid reaction times—a trait shaped by natural selection to maximize survival. However, rapid reactions are effective only when grounded in accurate judgments and appropriate choices, which often require cognitive c...

Subliminal cues accompanied by action generate temporal expectancy and the role of supraliminal experience

Sensory events associated with motor actions are critical for perceptual calibration and motor control. Due to the stable temporal relationships between these events, individuals can anticipate the timing of one event based on another. While temporal expectancy is well-establishe...

Cerebral venous thrombosis during pregnancy and the puerperium in the setting of hyperhomocysteinemia and methylenetetrahydrofolate reductase c.677 C > T polymorphism

Cerebral venous thrombosis (CVT) is an uncommon but serious complication of pregnancy and the puerperium that arises in a physiologically hypercoagulable milieu. Hyperhomocysteinemia (HHcy) is a recognized metabolic risk factor for venous thrombosis, and common variants in the me...

Interpersonal Relationships and Problematic Use of the Internet Among Adolescents: Between‐ and Within‐Person Perspectives

INTRODUCTION: Prior research has examined the role of interpersonal relationships in adolescents' problematic use of the internet (PUI). However, studies that examine the distinct contributions of various interpersonal relationships (i.e., with mothers, fathers, teachers, and pee...