Chinese Institute for Brain Research

Optimizing plasma-derived small extracellular vesicle purification to enhance downstream applications

Small extracellular vesicles (sEVs) are functional carriers of biomolecules from host cells, making them highly suitable for early disease diagnosis and monitoring disease progression. However, the purification of sEVs from plasma is complicated by the presence of high levels of...

Economic and social modulations of innate decision-making in mice exposed to visual threats

When confronted by predators, animals make innate decisions with rapid reaction times—a trait shaped by natural selection to maximize survival. However, rapid reactions are effective only when grounded in accurate judgments and appropriate choices, which often require cognitive c...

Subliminal cues accompanied by action generate temporal expectancy and the role of supraliminal experience

Sensory events associated with motor actions are critical for perceptual calibration and motor control. Due to the stable temporal relationships between these events, individuals can anticipate the timing of one event based on another. While temporal expectancy is well-establishe...

Cerebral venous thrombosis during pregnancy and the puerperium in the setting of hyperhomocysteinemia and methylenetetrahydrofolate reductase c.677 C > T polymorphism

Cerebral venous thrombosis (CVT) is an uncommon but serious complication of pregnancy and the puerperium that arises in a physiologically hypercoagulable milieu. Hyperhomocysteinemia (HHcy) is a recognized metabolic risk factor for venous thrombosis, and common variants in the me...

Interpersonal Relationships and Problematic Use of the Internet Among Adolescents: Between‐ and Within‐Person Perspectives

INTRODUCTION: Prior research has examined the role of interpersonal relationships in adolescents' problematic use of the internet (PUI). However, studies that examine the distinct contributions of various interpersonal relationships (i.e., with mothers, fathers, teachers, and pee...