Chinese Center For Disease Control and Prevention

Case-generating patterns of hemorrhagic fever with renal syndrome in Chinese mainland, 2006–2025: a national surveillance analysis

Hemorrhagic fever with renal syndrome (HFRS) shows marked spatiotemporal heterogeneity and frequent zero counts in Chinese mainland. We analysed monthly HFRS surveillance data from 352 cities during 2006–2025 using a zero-inflated time-series model incorporating meteorological, e...

Effects of metallic components in ambient PM₂.₅ on pediatric respiratory diseases in Shijiazhuang

Considerable attention has been paid to the short-term association between ambient PM 2.5 exposure and children’s respiratory health, yet evidence on individual and combined exposure to its metal components remains limited, especially in typical industrial cities. Based on daily...

Complex exposure–response relationships between meteorological factors and severe fever with thrombocytopenia syndrome risk

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease influenced by meteorological factors. This study aimed to characterize the complex exposure–response relationships between multiple meteorological factors and SFTS risk in Anhui Provin...

Prevalence and risk factors of comorbidities among Chinese older people living with HIV/AIDS: a cross-sectional study

With population aging among people living with HIV/AIDS (PLWHA), comorbidity has become a prominent challenge for long-term care. However, evidence on its prevalence and associated factors in Chinese community settings remains limited. We conducted a cross-sectional study among P...

Associations Between Maternal Pre-Pregnancy Dietary Patterns and Body Composition in Preschool Children: A Prospective Cohort Study

Background: Maternal nutritional status before pregnancy may influence offspring long-term health; however, the association between pre-pregnancy dietary patterns and body composition in preschool children remains unclear. Methods: This study used data from the Taicang and Wuqian...

Predictive association between control measures and chikungunya fever incidence based on random forest and SHAP analysis

Background Using the 2025 Chikungunya fever (CHIK) outbreak in Chancheng District, Foshan City, this study applied a random forest (RF) regression model combined with SHapley Additive exPlanations (SHAP) to explore predictive associations, nonlinear relationships and potential th...

Identifying factors influencing HIV testing behavior among high-risk elderly men: a mixed-methods study incorporating structural equation modeling and thematic framework

Abstract Background Population ageing has been accompanied by increasing HIV risk among older adults. Timely diagnosis and treatment are essential for improving health outcomes. However, over 65% of HIV cases among older men at elevated risk in China are diagnosed at an advanced...

Identification and characterization of ethR and ethA genes impacting the sensitivity of Mycobacterium abscessus to ethionamide

ABSTRACT Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium with rising global incidence. This pathogen exhibits intrinsic resistance to most antibiotics, presenting a major public health threat. Ethionamide (ETH) requires bioactivation by monooxygenase Et...

Protocol for the ACTIVE trial: a multicentre, open-label, cluster-randomized controlled trial of a quality improvement programme for older adults with hip fracture in resource-limited hospitals in China

Aims The primary aim of the Action on Hip Fracture Management Quality Improvement (ACTIVE) trial is to evaluate whether a context-tailored quality improvement programme improves health-related quality of life at 120 days after hospital admission, among adults aged 65 years or old...

Plant-based diet and risk of cognitive decline among older adults: a community-based prospective cohort study

Background: Diet serves as a modifiable risk factor for cognitive decline, yet evidence on plant-based diets and cognitive ageing remains limited. We examined the association between plant-based diets and cognitive decline.Methods: A total of 6,721 participants from the Chinese L...

FOXA2 Transcriptionally Activates SIRT1 to Inhibit Cochlear Ferroptosis in Noise-Induced Hearing Loss

Background: Noise-induced hearing loss (NIHL) is a pervasive occupational health challenge, yet the individual susceptibility mechanisms remain unclear. Ferroptosis, an iron-dependent form of programmed cell death, has been implicated in cochlear hair cell damage. This study aims...

From raw to cooked: The impact of cooking on bioaccessibility and health risks of toxic elements in leafy vegetables

Environmental policies in China have significantly reduced toxic element fluxes in soil and air, but slower declines in atmospheric toxic element flux have increased its relative contribution to crop contamination. Leafy vegetables, with their large surface area and high capacity...

Temporal trends and age-period-cohort effects of tuberculosis incidence among older adults in western China, 2005–2020

Abstract Background Tuberculosis remains a major public health challenge in China, and older adults in western China bear a disproportionate burden. This study examined the temporal trends in TB incidence among older adults in western China and assessed the independent effects of...

Prevalence of Keshan disease at the township level in China: a cross-sectional study

Keshan disease (KD), an endemic myocardiopathy with unclear etiology, lacks primary preventive measures. This study aimed to assess the prevalence of KD at the township level using spatial epidemiology, elucidate its distribution characteristics for further precision classificati...

Longitudinal TyG index trajectories and renal function decline in a high cardiovascular-risk Chinese cohort: a sex-stratified analysis

This study aimed to identify longitudinal triglyceride-glucose (TyG) index trajectories and evaluate their association with annual estimated glomerular filtration rate (eGFR) change in a high cardiovascular-risk Chinese cohort, with sex-stratified analyses. A prospective cohort a...