Chinese Academy of Engineering

Mitochondria-Targeted Prodrug Nanoassemblies Elicit Antitumor Immunity via Mitophagy-Boosted Ferroptosis in Triple-Negative Breast Cancer

Abstract Ferroptosis, an immunogenic iron-dependent cell death driven by lipid peroxidation, holds promise for treating triple-negative breast cancer (TNBC). However, its efficacy is severely compromised by restricted iron availability and the potent GPX4/GSH defense system. Here...

Miniaturized Full-Stokes Spectrometers Based on Low-Correlation Metasurface Array

Abstract Full-Stokes spectrometers hold an immense application value due to their capability to simultaneously resolve polarization state and spectral information. Specifically, miniaturized full-Stokes spectrometers are promising for applications in real-world scenarios owing to...

Phosphoric Acid Cross-linking Regulates Closed Pores for Scalable Hard Carbon Anodes

Abstract The low-voltage capacity of hard carbon anodes, governed by closed-pore structures, directly determines the energy density of Na-ion batteries (NIBs), yet rational regulation of closed pores remains challenging. Herein, we report a phosphoric acid-induced cross-linking s...

Stabilizing Macrophage Immune States through Fusion-Enabled Nanoparticle-Based Intracellular Drug Depots for Durable Ulcerative Colitis Therapy

Abstract Ulcerative colitis (UC) is characterized by persistent colonic inflammation accompanied by the accumulation of pro-inflammatory M1-like macrophages, which sustain cytokine production and impair mucosal repair. Promoting a shift toward a pro-resolving M2-like phenotype is...

A Carfentanil-Targeted Vaccine Adjuvanted with a Covalent TLR7/8 Agonist and a T-Helper Epitope Confers Protective Immunity against Carfentanil-Induced Effects

Abstract Carfentanil, an ultrapotent synthetic opioid, poses a severe public health threat because of its rapid brain penetration and potent activation of μ-opioid receptors. Conventional anti-drug vaccines are limited by the poor hapten immunogenicity and dominant anti-carrier i...

An N , N -Dimethylethylenediamine-Derivatized In Silico Mass Spectral Library for Comprehensive Profiling of Isothiocyanates in Brassicaceae Plants

Abstract Isothiocyanates (ITCs) are bioactive hydrolysis products of glucosinolates in Brassicaceae plants with diverse health-promoting properties. However, comprehensive profiling of ITCs remains challenging due to the limited availability of authentic standards, the underexplo...

A Self-Sufficient Photocatalytic CO2 Reduction over Ionic Liquid-Modified Three-Dimensional-Printed Pt Single-Atom TiO2 Nanosheets

Abstract The photocatalytic carbon dioxide reduction reaction (CO2RR) offers a promising route to convert waste CO2 into valuable synthetic fuels and chemicals using solar energy. However, practical application is hindered by insufficient charge separation, weak CO2 activation, a...

Structure-Based Optimization of 2-Aminopyrimidine Derivatives as Potent Multi-target FLT3/CHK1/IRAK4 Inhibitors for Acute Myeloid Leukemia

Abstract The efficacy of FLT3 inhibitors is limited by resistance. Co-inhibiting FLT3 and CHK1 can overcome FLT3i resistance, and IRAK4 signaling contributes to leukemic cell survival in FLT3-mutant acute myeloid leukemia (AML). We discovered a novel series of 2-aminopyrimidine d...

Enantioselective Defluorinative C(sp2)–H Allylation of Acrylamides Enabled by CpxRh(III) Catalysis

Abstract Chiral fluoroalkenes are high-value synthetic targets; however, the development of efficient catalytic asymmetric methods for their assembly from abundant precursors remains a formidable challenge. Herein, we report a convergent strategy that merges asymmetric alkenyl C(...

Lewis Acidic Zn/S-1 Zeolite Enables Direct Dehydrogenative Aromatization of Long-Chain Olefins

Abstract Aromatics, as essential chemical feedstocks, are predominantly derived from nonrenewable petroleum resources. With the rapid advancement of syngas–to–olefins (STO) technology, Fischer–Tropsch (F–T) olefin aromatization has emerged as a promising alternative route for aro...

Bioenergetics Underpins Both Heat–Pesticide Synergisms and Their Transgenerational Offsetting in Water Fleas

Abstract Freshwater ecosystems are increasingly threatened by interacting stressors simultaneously or sequentially, such as pesticide contamination and extreme heat events. Although synergistic interactions between these stressors within a generation are well documented, their tr...

Ternary-Ion Batteries

Abstract The advancement of rechargeable batteries has long been dominated by two principal paradigms: single-ion and dual-ion mechanisms. The single-ion mechanism, operating via the shuttling of monovalent cations, offers high energy density yet suffers from inherent kinetic lim...

Phase Boundary Engineering Enables Multivalley Activation for High-Performance ZrCoSb Half-Heuslers

Abstract P-type ZrCoSb-based half-Heusler compounds are promising thermoelectric materials for high-temperature power generation because of their excellent thermal stability and mechanical robustness. However, their performance still lags behind that of state-of-the-art p-type Zr...

Physics-Informed Structural Attention Unlocks Efficient and Interpretable Inverse-Designed Photonic Devices

Abstract Photonic inverse design has attracted widespread attention due to its advantages in realizing high-performance and compact optical devices. Analog metamaterials offer design flexibility through freeform geometries, but their fabrication requires additional enforcement of...

Single Transition-Metal-Anchored γ-Graphyne as a Promising Nonlinear Optical Material: A DFT Investigation

Abstract Two-dimensional carbon nanomaterials with illustrious nonlinear optical (NLO) performance are highly favored in the fields of advanced optoelectronic and laser protection technologies. Herein, structural stability, electronic characteristics, and NLO responses of a serie...

Novel Coumarin Derivatives Containing Oxazole/Isoxazole/Pyrazole Groups as Antifungal Agents: Design, Synthesis, Quantitative Structure–Activity Relationships, and Preliminary Mechanistic Insights

Abstract Plant pathogenic fungi pose a significant threat to global crop productivity and food security. Herein, we report the design and synthesis of 55 coumarin–oxazole, −isoxazole, and −pyrazole hybrids as novel antifungal agents. Most derivatives exhibited notable potency, wi...

Interpretable Spatiotemporal Coupling Network for Robust Emission Prediction and Implicit Mechanism Mining in Sludge Gasification

Abstract Thermochemical gasification is a vital green technology for sewage sludge reduction and resource recovery, yet real-time emission forecasting remains exceptionally challenging due to chaotic operational fluctuations, pronounced time lags, and noisy sensor data. Conventio...

MonoXtract: A Deep Learning Framework for Extracting Transmembrane Protein Dynamics from Single-Color Single-Molecule Imaging

Abstract Single-color fluorescence-based single-molecule techniques enable label-efficient probing of membrane-associated biomolecular dynamics. However, extracting reliable kinetic information is challenging due to signal heterogeneity, noise and the absence of reference channel...

Neurodevelopmental Toxicity of Tris(2,4-di- tert -Butylphenyl)phosphate: Mechanistic Insights from Laboratory Models and Implications for Human Health

Abstract Organophosphite antioxidants (OPAs) and their transformation products, novel organophosphate esters (NOPEs), are ubiquitous environmental contaminants, yet their toxicological profiles remain poorly understood. This study systematically characterized the neurodevelopment...

On-Surface Molecular Design and Synthesis of Discrete Metal–Fullerene Complexes on Graphite

Abstract On-surface synthesis enables the fabrication of molecular complexes, which cannot be obtained through traditional solution chemistry. Generally, metal substrates have been used due to their catalytic properties. Here, a tripod-like magnetic molecular complex, (C60)3–Co,...