China-US (Henan) Hormel Cancer Institute

The SF3b complex in cancer: structural basis, molecular mechanisms, and therapeutic opportunities

Aberrant alternative splicing is increasingly recognized as a fundamental driver of cancer initiation and progression. The splicing factor 3b (SF3b) complex, an essential component of the U2 small nuclear ribonucleoprotein (snRNP), plays a pivotal role in branch point sequence (B...