China-US (Henan) Hormel Cancer Institute

3-O-Acetylrubiarbonol B induces apoptosis of colorectal cancer cells by activating JNK/p38 MAPK and ROS generation

Colorectal cancer (CRC) continues to be a significant health issue, claiming millions of lives each year. The challenge is exacerbated by resistance to anticancer treatments, which reduces therapeutic effectiveness and calls for strategies to combat drug-resistant cancer. In this...

The SF3b complex in cancer: structural basis, molecular mechanisms, and therapeutic opportunities

Aberrant alternative splicing is increasingly recognized as a fundamental driver of cancer initiation and progression. The splicing factor 3b (SF3b) complex, an essential component of the U2 small nuclear ribonucleoprotein (snRNP), plays a pivotal role in branch point sequence (B...