China Medical University Hospital

Thermal-economic performance assessment of heat recovery-oriented design of integrated CCHP-H₂ system; multi-objective optimization with LCA and AdaBoost decision-making

Combined cooling, heating, power systems integrated with hydrogen production (CCHP–H₂) can simultaneously supply useful outputs while improving the utilization of fuel and recoverable thermal energy. The present project proposes a methane-fueled CCHP–H₂ configuration integrating...

Multi-Locus Molecular Findings in Pediatric-Onset Inherited Metabolic Disorders: An Eight-Year Series of Outsourced Genomic Testing in Taiwan

Background/Objectives: Outsourced genomic testing can identify additional findings in patients with inherited metabolic disorders (IEMs), including lysosomal storage diseases. We examined these findings in a selected Taiwanese series. Methods: We retrospectively reviewed 13 patie...

Coderivatives with Respect to a Set of the Normal Cone Mappings and Their Applications

Abstract. Establishing explicit formulas of coderivatives with respect to a set of the normal cone mapping to a polyhedron, the solution set of a variational inequality system, is one of the main goals of this paper. By using our coderivative formulas, we provide a characteristic...

Treatment-Free Interval as a Prognostic Factor for Survival Outcomes in Patients with Advanced or Recurrent Endometrial Cancer Treated with Pembrolizumab Plus Lenvatinib: A Multi-Institutional Real-World Cohort Study

Background/Objectives: The treatment-free interval (TFI) predicts benefit from platinum rechallenge in gynecological cancers, but its prognostic value in patients receiving second-line pembrolizumab plus lenvatinib for recurrent endometrial cancer (EC) is unknown. We evaluated wh...

Progressive Conduction System Disease Preceding Hypertrophy in IVS4 + 919G > A Fabry Variant: a Population-based Electrocardiographic Study

BACKGROUND: The IVS4 + 919G > A variant is the most prevalent late-onset Fabry variant in East Asian populations, but its electrophysiological trajectory remains incompletely defined. METHODS: From a regional genetic screening program, 905 IVS4 + 919G > A carriers were identified...

Association of allergic rhinitis with polysomnographic arousal indices in children with sleep-disordered breathing

Abstract Background Children with allergic rhinitis (AR) frequently experience sleep disruption and have a higher prevalence of sleep-disordered breathing (SDB). However, the specific impact of AR on sleep architecture across different SDB subtypes, such as obstructive sleep apne...

Frontline bevacizumab in ovarian clear cell versus high-grade serous ovarian cancer: survival outcomes and recurrence patterns in a real-world cohort

Ovarian clear cell carcinoma (OCCC) is associated with inferior survival compared to high-grade serous ovarian cancer (HGSOC), largely due to its relative chemoresistance and near-universal BRCA wild-type status. Whether frontline bevacizumab can mitigate this survival disadvanta...

Prognostic significance and molecular implication of microRNAs in hepatocellular carcinoma following curative surgical resection

Although various advanced therapeutic strategies exist for hepatocellular carcinoma (HCC), it continues to rank among the primary drivers of cancer-related fatalities worldwide. Resection surgery offers a cure for HCC, but a high recurrence rate severely limits patient survival....

Sex differences in the associations of body composition and PPARGC1A genetic variants with elevated pulse pressure

Pulse pressure (PP) is a hemodynamic marker for vascular aging. We investigated the sex-specific associations of bioelectrical impedance analysis (BIA)-derived body composition indices and PPARGC1A/VDR variants with elevated PP risk. This community-based study analyzed 5,829 adul...

High‐Resolution IVIM MRI Characterizes Diffusion–Perfusion Properties of the Parasagittal Dura

The objectives of this study were to characterize the diffusion-perfusion properties of the parasagittal dura (PSD) using high-resolution intravoxel incoherent motion (IVIM) MRI and to explore whether PSD-specific IVIM metrics reflect distinct fluid-transport-related signal behav...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework

Inherited mitochondrial cardiomyopathies arise from pathogenic variants affecting oxidative phosphorylation, mitochondrial DNA maintenance, cardiolipin remodeling, protein import, cofactor metabolism, and mitochondrial dynamics or proteostasis. These disorders may be cardiac-pred...

Telephone sequence spaces and associated theory of matrix transformation and compactness

Given a non-negative integer k, T_k be the k^{th} telephone number. Let us define a matrix T=( T_{k,m} ) with entries for k,m=0,1,2,⋯. Based on T, the matrix domains T_0 and T_c are defined. Schauder bases are constructed for these spaces, and their α-, β-, and γ-duals are charac...

Nonsurgical Platelet Membrane-Decorated Gold Yarnball Brain Antenna for In Situ Nitric Oxide Generation and Neuronal Regeneration

Bioelectronic implants for brain stimulation are widely used to treat neurological disorders and promote neuronal repair; however, their clinical application is limited by invasive surgical implantation. To address this challenge, here, platelet membrane-decorated gold yarnballs...

Chinese herbal medicine therapy reduces all-cause and cardiovascular disease-related mortalities in acquired hemolytic anemia: A Taiwanese nationwide retrospective cohort study

Objectives To assess whether Chinese herbal medicine (CHM) treatment was associated with all-cause and cardiovascular disease (CVD)-related mortality in Taiwanese patients with acquired hemolytic anemia (AHA). Design & setting This population-based retrospective cohort analysis u...

scTransMIL bridges patient-level disease states and single-cell transcriptomics for cancer screening and heterogeneity inference

Single-cell sequencing offers profound insights into tumor complexity. However, reliably linking individual cellular profiles to overall sample-level phenotypes remains computationally challenging, particularly when cell-specific annotations are absent. This disconnect limits the...

Automated CT-Based Quantification of Pulmonary Fibrosis Using Deep Learning-Based Lung Segmentation

Background/Objectives: To develop and evaluate an automated CT-based framework for the quantitative assessment of fibrotic interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), using a standardised six-level anatomical protocol and deep-learning lung seg...

Machine Learning Model for Predicting Hepatocellular Carcinoma Development in Patients With Hepatitis B Virus‐Related Cirrhosis Receiving Antiviral Therapy

Few prediction models have been specifically designed to evaluate the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B and cirrhosis. This study aimed to develop a machine learning-based prediction model to assess the risk of developing HCC in patients...

Hepatitis B virus reactivation risk in haploidentical versus matched donor transplantation: Impact of universal prophylaxis

Background Hepatitis B virus reactivation is a serious complication of allogeneic hematopoietic cell transplantation, particularly in endemic regions. Patients with HBsAg-negative/anti-HBc-positive serology represent an intermediate-risk group due to occult hepatitis B virus infe...

Effect of APOE and LPA genotypes on the risk of dementia after myocardial infarction: a clinic-based cohort study

Survivors of myocardial infarction (MI) face elevated risk of subsequent cognitive decline, yet the relative contributions of neurodegenerative susceptibility ( APOE4 ) and lipid-mediated vascular burden ( LPA risk variants) to post-MI dementia remain unclear, particularly in Asi...