China International Science and Technology Cooperation

Differential efficacy and safety of ruxolitinib in primary versus secondary hemophagocytic lymphohistiocytosis: a systematic review and meta-analysis

Ruxolitinib (RUX), a JAK1/JAK2 inhibitor, has demonstrated therapeutic potential in both primary and secondary hemophagocytic lymphohistiocytosis (pHLH & sHLH), but quantitative evidence comparing its efficacy and safety across subtypes remains lacking. Given the absence of rando...

Performance of an unmanned sailboat towing a sonar array system in various wind conditions

This paper proposes a novel unmanned sailboat towing a towed array sonar system (USTAS) and develops a framework for evaluating its speed performance in calm water under both steady and unsteady wind conditions. This study represents the first application of a previously develope...

Crystal Creeping for Spatial Gradient Partitioning: A New Pre-Enrichment Strategy Assisting Multicomponent Crystallization Separation

Abstract Based on the significant difference in interfacial creeping behavior between ammonium chloride (NH4Cl) and hexamethylenetetramine (C6H12N4, HMTA), this work proposes a spatial gradient-based pre-enrichment strategy for multicomponent mixtures. Unlike conventional sequent...

Hybrid long-read sequencing reveals genomic homogeneity, blaZ copy-number variation, and phenotypic adaptation of the emerging Asian ST188 MSSA lineage from pediatric gut and vaginal colonization sites, Southern China

Staphylococcus aureus ( S. aureus ) ST188 has emerged as an important methicillin-susceptible clonal lineage in Asia and is frequently associated with human colonization and community-acquired infections. This study investigates ST188 isolates from aerobic vaginitis and pediatric...

Organizing Large GTPase Atlastin‐Mediated Membrane Fusion by Programmable DNA Origami Platforms

ABSTRACT In eukaryotic cells, the endoplasmic reticulum (ER) utilizes membrane fusion to form interconnected networks. GTP hydrolysis‐triggered conformational changes in ER‐anchored atlastins (ATLs) have been shown to be responsible for this process, which is facilitated by the a...