China Academy of Chinese Medical Sciences

Metabolitic and transcriptional network in seeds germination of Ephedra sinica by inoculating with endophytic Fusarium citricola of mutualistic symbiosis

The poor germination of seeds from the renowned medicinal plant Ephedra sinica poses a significant challenge in production. An endophytic fungus was isolated from the roots of E. sinica , named Fusarium citricola (EBS-22), which exhibits seed germination-promoting activity. Howev...

Acupuncture and Moxibustion for Neck Pain: A Clinical Practice Guideline

ABSTRACT Background Neck pain (NP) is a leading cause of disability worldwide. Pharmacological treatments often provide limited benefits and may be associated with adverse effects, highlighting the need for effective non‐pharmacological options. Aim To develop evidence‐based reco...

Cannabidiol Alleviates Aβ1–42-Induced Cognitive Deficits and Neuronal Injury Associated with Modulation of the AEA–FAAH–CB1R Axis and BDNF/TrkB Signaling

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and neuronal injury. Cannabidiol (CBD), a non-psychoactive constituent of Cannabis sativa L., has neuroprotective potential, but its underlyi...

Chemical Stabilization and Retention-Predictive Modeling for Regiospecific Profiling of Labile Monoacylglycerols by UHPLC–HRMS

Abstract Regiospecific analysis of monoacylglycerols (MAGs) remains challenging because of their low endogenous abundance, the limited availability of regioisomeric standards, and rapid acyl migration between the sn-1 and sn-2 positions during sample handling. Here, we report an...

Protective effects of icariin in atherosclerotic cardiovascular disease: mechanistic basis, post-ischemic protection and translational limitations

CONTEXT: Icariin (ICA), a prenylated flavonol glycoside from Epimedii Folium, has been investigated in experimental models relevant to atherosclerosis, myocardial infarction, and ischemic tissue injury. OBJECTIVES: This review evaluates experimental evidence on ICA in atheroscler...

Enhancing Natural Product Therapy with PROTACs: Targeted Degradation of TLR4 Confers Potent Endothelial Protection

Abstract TLR4-MyD88-mediated endothelial dysfunction drives cardiovascular disease. To overcome the weak efficacy of ferulic acid, we synthesized six ferulic acid-based PROTAC derivatives. Migration and TLR4 expression assays in HUVECs identified FP-4 as lead. FP-4 induced the ta...

Integrating experimental paper analysis into traditional ancient book restoration: A case study of the Chinese medical text Yi Men Pu Du

Background Ancient Chinese books represent irreplaceable cultural heritage, yet many suffer severe deterioration from acidification, insect damage, and mechanical degradation. Traditional restoration practices rely heavily on empirical experience, with limited integration of scie...

Magnoflorine Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Targeting the NDUFV1 Subunit of Complex I to Regulate the ROS/AMPK Signaling Pathway

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder with limited therapeutics. Magnoflorine (MAG), a natural alkaloid from edible plants, ameliorates MASLD; however, its direct targets remain unclear. Here, by integrating th...

Enhancing FAIR data practices in China: An integrated strategy for biomedical research

The construction of scientific data compliant with FAIR (Findability, Accessibility, Interoperability, and Reusability) principles has become a consensus in the biomedical field. However, FAIR is often implemented at the data submission stage, leading to suboptimal outcomes, such...

Association Between Rest–Activity Rhythm and Cardiovascular Disease, Cardiovascular Mortality, and All‐Cause Mortality: A Systematic Review and Meta‐Analysis

BACKGROUND: Disruption in rest-activity rhythm (RAR) is an emerging risk factor for cardiovascular disease (CVD) and mortality, but the strength of evidence is unclear. Therefore, we conducted a systematic review and meta-analysis to assess associations between RAR characteristic...

Shared oral microbiome signatures linking periodontitis and autoimmune thyroiditis: NHANES 2009–2012

Objective To examine the association between periodontitis severity and autoimmune thyroiditis (AIT) in a nationally representative US sample and to explore oral microbiome features shared between the two conditions.Methods We analyzed adults from NHANES 2009–2012 with complete p...

Luteolin alleviates myocardial fibrosis through the ERK1/2-GATA4 pathway by inhibiting oxidative stress and EndMT

Introduction Myocardial fibrosis is a common pathological feature of cardiovascular diseases and is closely associated with oxidative stress, apoptosis, extracellular matrix remodeling, and endothelial-to-mesenchymal transition (EndMT). Luteolin (Lut), a naturally occurring flavo...

Clinical Value of an LDH–CA125–NLR Panel for Diagnosis, Platinum Resistance, and Prognostic Assessment in Epithelial Ovarian Cancer

(1) Background/Objective: Routine blood tests may provide useful information at different stages of epithelial ovarian cancer (EOC) management. This study evaluated continuous lactate dehydrogenase (LDH), carbohydrate antigen 125 (CA125), and neutrophil-to-lymphocyte ratio (NLR)...

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-aging compounds from Dengzhan Shengmai formulation

Aging is a complex biological process involving multiple dysregulated pathways, and synergistic compound combinations offer distinct therapeutic advantages through multi-target and multi-pathway interactions. Traditional Chinese Medicine (TCM) formulations are inherently synergis...

Diabetic plaque calcification: mechanisms, imaging phenotypes, and clinical implications

Diabetes is associated with a higher burden and heterogeneous phenotypes of plaque calcification, which may influence plaque stability and cardiovascular risk. This review examines diabetic plaque calcification as a dynamic process driven by hyperglycemia and other metabolic dist...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

A MultitaskLarge Reasoning Model for Molecular Science

Abstract Artificial intelligence in molecular science must move beyond pattern recognition toward chemically valid and interpretable reasoning. We present a task-adaptive large reasoning model that integrates chemical knowledge through a synergistic multispecialist architecture,...

Development and multicenter validation of a predictive nomogram for infection risk in patients with multiple myeloma

To explore the key influencing factors of the risk of nosocomial infection in patients with multiple myeloma (MM), to construct a prediction model to effectively assess the risk of infection, and to provide a basis for individualized infection prevention and control. 245 patients...

Integrated Chemical, Computational, and Cellular Profiling of a Dual-Oil Melanoma Formulation: An Exploratory Life-Science Study

Background: Previous studies have examined bioactive constituents of Prunus dulcis oil, Pinus sylvestris essential oil, and related phytochemical matrices separately; however, their combined chemical profile, comparator-context molecular-docking landscape, and comparative cellula...