Children's Memorial Health Institute

Ambroxol in Gaucher disease and GBA1-related Parkinson disease: an updated systematic review

Abstract Background Ambroxol (ABX) is a central nervous system (CNS)-penetrant compound that can increase glucocerebrosidase activity and has been investigated in Gaucher disease (GD) and GBA1 -related Parkinson disease ( GBA1 -PD). Methods This PRISMA 2020 systematic review and...

Selective immunoglobulin A deficiency and coeliac disease: Immune response dynamics

Abstract Objective To analyse the serological immune response in paediatric patients with selective immunoglobulin A deficiency (SIgAD) and coeliac disease (CeD), focusing on immunoglobulin G antibody dynamics after starting the gluten‐free diet (GFD). Methods Data from SIgAD pat...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Association of three different dietary patterns with the metabolomic profiles of children: the BiomarKid project

Abstract Background and aims Metabolomics offers a promising approach to objectively assess food intake and nutrition-related health risks. Three different dietary patterns (DPs) associated with cardiometabolic health were previously identified at 2 years of age in the EU Childho...

Surgical Ablation for Atrial Fibrillation During Minimally Invasive Mitral Valve Surgery: Risk Dependencies and Long-Term Survival

Objective: Atrial fibrillation (AF) is a common finding among patients with mitral valve disease, with a growing body of evidence showing survival benefits associated with surgical ablation (SA). However, a lack of data persists regarding the safety and survival after SA concomit...

Results of the meeting of the Interdisciplinary Expert Council on an integrated approach to the management of peri- and postmenopausal women with psycho-emotional and neurological disorders

The reduction in sex hormone levels during the menopausal period substantially impacts patients' quality of life and serves as a significant risk factor for psycho-emotional disorders. Current clinical guidelines from both Russian and international sources recognize menopausal ho...

Vaccination in pediatric transplantation—General recommendations. A position paper by the European Reference Network TransplantChild

Infectious diseases remain a leading cause of morbidity and mortality among pediatric transplant recipients, despite significant advances in transplantation management. Vaccination is the most effective strategy to prevent infections; however, its efficacy is hindered in solid or...

Results of the meeting of the Interdisciplinary Expert Council on an integrated approach to the management of peri- and postmenopausal women with psycho-emotional and neurological disorders

The reduction in sex hormone levels during the menopausal period substantially impacts patients’ quality of life and serves as a significant risk factor for psycho-emotional disorders. Current clinical guidelines from both Russian and international sources recognize menopausal ho...