Children's Medical Center

Design of a prediction system for intravenous immunoglobulin resistance in hospitalized Kawasaki disease patients with artificial intelligence based on machine learning

Machine Learning (ML) algorithms are widely used as a prediction tool in medicine to support clinical decisions. In this study, the machine learning methods are used to investigate IVIG resistance in Kawasaki disease in a referral center of Iran. This is a retrospective cross-sec...

Human-inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity

Abstract We previously reported inherited RORγT deficiency in seven patients from three ancestries (Chilean, Palestinian, Saudi Arabian) with mycobacterial disease and chronic mucocutaneous candidiasis (CMC). We report here five additional patients from different ancestries (Afgh...

Establishing MRI-based thresholds for corpus callosum in children aged 1–6: a comparison of typical development and cerebral palsy-associated morphometry

The corpus callosum (CC) is central to neurodevelopment, and morphometric abnormalities are linked to atypical development. This study aimed to establish age-dependent and age-independent MRI-based cutoffs defining normative CC morphology in children aged 1–6 years, distinguishin...

A brucellosis-associated vasculopathy presenting with focal neurological deficit: a case report in a pediatric patient with unique imaging

Brucellosis is the most prevalent bacterial zoonosis worldwide. While neurobrucellosis occurs in 5–7% of the affected adults, it is a rare pediatric complication, with an estimated incidence of 0.8%. Limited knowledge of its presentations, diagnosis, and management leads to a sig...

Impact of carotenoids on body composition and adipokine hormones: a systematic review and meta-analysis of randomized controlled trials

Carotenoids, a class of antioxidant phytochemicals, have been proposed to influence adiposity and metabolic regulation through modulation of oxidative stress, inflammation, and adipokine secretion. However, clinical evidence remains inconsistent. This systematic review and meta-a...