Children’s Institute

Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency

Abstract Medulloblastoma is a biologically heterogeneous childhood cerebellar tumor harboring frequent chromatin-modifying gene alterations. How these alterations promote transcriptional programs governing malignancy remains poorly defined. To address this knowledge gap, we evalu...

AI Accelerated Chemical Screening Integrates ChemBERTa to Identify Repositionable CASP4 Inhibitors via MD Simulations and MM/PBSA Analysis

Abstract This study employed an integrated ligand-based virtual screening pipeline to identify potential CASP4 inhibitors from the DrugBank database, leveraging docking-score prioritization, SMILES-derived ChemBERTa embeddings, and key physicochemical descriptors. Building on thi...

Social Functioning Profiles in Children with Autism Spectrum Disorder in China: A Preliminary Identification of Subtypes

Children with autism spectrum disorder (ASD) exhibit considerable heterogeneity in social functioning, suggesting the existence of distinct latent subtypes. A total of 479 Chinese children diagnosed with ASD (Mage = 9.338 years) were assessed using the Mandarin translation of the...