Children's Hospital Research Institute of Manitoba

ATF6 shapes PERK and IRE1 signaling dynamics during ER stress

Abstract The Unfolded Protein Response (UPR) is a conserved network of signaling pathways controlled by the Endoplasmic Reticulum (ER) anchored stress sensors IRE1, PERK and ATF6. The UPR’s primary function is to help cells manage and resolve ER stress. Compared with the well-cha...

Shared patterns of human milk composition link mammary gland function to infant growth

The mammary gland produces nutrient-rich human milk (HM), yet how mammary functional state shapes HM composition and infant outcomes remains poorly understood. We used HM multi-omics - metabolomics, proteomics, micronutrients, macronutrients, and HM oligosaccharides - across 1,54...

Theory–simulation–application framework to enhance biostatistical capacity for HIV and cancer data analysis in sub-Saharan Africa: lessons learnt from Tanzania

Enhancing biostatistical capacity in sub-Saharan Africa (SSA) is imperative for the efficient analysis of routinely collected health data and for clinical and public health decision-making. We describe the experiences and lessons learnt from implementing advanced statistical capa...

Diabetes and Driving: How Predictive Technologies Will Alter Ethical and Legal Responsibilities

In 2023, a 67-year-old man with long-standing type 1 diabetes experienced a severe hypoglycemic episode and drove into an outdoor dining area in Victoria, Australia, killing 5 people and injuring several others. Although the charges against the driver were dismissed, future cases...

Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation

Interactions among molecular recognition systems, neuronal activity, and glial regulation transform early neuronal connectivity into precise functional circuits during brain development. The cerebellum is a powerful model for studying these mechanisms due to its stereotyped and a...

Dr. Tsai et al reply

We appreciate the interest of Drs. Wang and Qu¹ in our work,² and their call for more family-friendly metrics to help convey meaningful quality of life improvements in juvenile idiopathic arthritis ( JIA). After considering the different ideas suggested in t...

Virtual Health Interventions to Improve Breastfeeding: A Systematic Review

CONTEXT Use of virtual health interventions has increased rapidly, with growing evidence evaluating virtual breastfeeding support. However, the effectiveness of different types of virtual breastfeeding interventions remains unclear. OBJECTIVE To examine the effects of various typ...