Children's Hospital of Zhejiang University

Measurable residual disease detected by next-generation sequencing in T-cell acute lymphoblastic leukemia

The clinical utility of measurable residual disease monitoring based on next-generation sequencing in T-cell acute lymphoblastic leukemia remains incompletely defined. Here we show the prognostic value of tracking clonal T-cell receptor gene rearrangements by next-generation sequ...

Uncovering the microbiota-metabolite axis across levels of metabolic complication burden in Chinese adolescents with obesity

Pediatric obesity presents with diverse metabolic phenotypes, yet the gut microbiota and metabolite signatures associated with obesity-related metabolic complications remain poorly defined. Here, we applied 16S rRNA gene sequencing and untargeted fecal metabolomics to investigate...

Nickase-based suppression of self-ligation in long sticky-end adapters for next-generation sequencing library preparation

The correctness and efficiency of the adapter connection are important factors affecting the quality and yield of the libraries in next-generation sequencing (NGS). Lengthening the sticky ends of the adapters and the targets can effectively improve the efficiency of ligation, how...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...

Effect of postpartum probiotic supplementation on breastmilk composition and infant health: a pilot randomized controlled trial

Breast milk is the optimal infant nutrition, and its composition is influenced by maternal factors including supplement intake. This study aimed to investigate the effects of postpartum probiotic supplementation on breast milk composition and infant health outcomes. This double-b...