Children's Hospital of Zhejiang University

Oral Propranolol Versus Topical Timolol for the Treatment of Infantile Haemangiomas: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

ABSTRACT Aim This systematic review and meta‐analysis aimed to compare the efficacy and safety of oral propranolol versus topical timolol for the treatment of superficial infantile haemangiomas. Methods We systematically searched PubMed, Cochrane Library, Embase, Web of Science a...

Invasive Pneumococcal Disease in Children: A Retrospective Three-Center Study in Zhejiang Province, China (2010–2024)

Invasive pneumococcal diseases (IPD) are among the leading causes of global child mortality. Pneumococcal conjugate vaccines provide direct protection against IPD caused by serotypes included in the vaccine. To investigate the clinical characteristics, serotypes, and antibiotic r...

Genomic characterization of carbapenem-resistant organisms from pediatric patients with hematological malignancies and genomic comparison of infection versus intestinal colonizing strains

ABSTRACT This study aimed to characterize the species distribution, sequence types, and antimicrobial resistance mechanisms of carbapenem-resistant organisms (CROs) in pediatric patients with hematological malignancies, and to clarify the genomic relationship between clinical inf...

Helicobacter pylori-related peptic ulcer presenting as isolated iron deficiency anemia without typical gastrointestinal complaints in a child: a case report

Iron deficiency anemia (IDA) is the most common form of nutritional anemia in children worldwide. Helicobacter pylori (H. pylori) infection is a well-recognized contributor to pediatric IDA, through mechanisms including bleeding from peptic ulcers or erosions and impaired iron ab...

Positional and morphological characteristics of palatally impacted maxillary central incisors

Palatally impacted maxillary central incisors are commonly caused by obstructive phenomena and trauma, predisposing them to root dilaceration and subsequent aesthetic and functional complications. The three-dimensional intraosseous position of maxillary central incisors dictates...

Shared Genetic and Regulatory Architecture of Congenital Heart Disease and Autism Spectrum Disorder Revealed by Cross-Tissue Multi-Omic Integration

Background: Congenital heart disease (CHD) and autism spectrum disorder (ASD) co-occur more frequently than expected, suggesting shared developmental susceptibility. We aimed to identify cross-tissue molecular candidates linking cardiac and neurodevelopmental abnormalities. Metho...

Clinical phenotypic and genotypic analysis of Gitelman syndrome in children

Gitelman syndrome (GS) is a rare autosomal recessive tubulopathy caused by SLC12A3 variants, leading to hypokalemic metabolic alkalosis and other electrolyte disturbances. This study aimed to investigate the genotype and clinical phenotype in pediatric patients with GS. This stud...

Laparoscopic one-stage operation for completely perforated choledochal cyst: two cases report and review of the literature

Choledochal cyst (CDC) perforation is a rare but serious complication, and the optimal surgical strategy remains controversial. To our knowledge, no case of laparoscopic one-stage surgery for a completely perforated CDC with a perforation time exceeding 24 h has been reported. We...

Preliminary exploration of tissue oxygen saturation index using near-infrared spectroscopy in two infants of neonatal catheter-associated venous thrombosis

Near-infrared spectroscopy (NIRS) is commonly used for monitoring oxygen saturation in brain and abdominal tissues, while reports on the monitoring of local tissue oxygen saturation in limbs are very limited. This study observed the changes in limb tissue oxygen saturation index...

Association between chest CT features and disease severity in children with human bocavirus mono-infection: a retrospective cohort study

Human bocavirus (HBoV) is an established cause of pediatric lower respiratory tract infection, but the clinical relevance of chest CT findings in HBoV mono-infection remains uncertain. We retrospectively studied hospitalized children (< 18 years) with PCR-confirmed HBoV mono-infe...

Interventional bronchoscopy for diagnosis and airway recanalization in a child with endobronchial diffuse large B-cell lymphoma

Endobronchial involvement by diffuse large B-cell lymphoma (DLBCL) is rare in children, particularly in the setting of Epstein–Barr virus (EBV)-associated lymphoproliferation. We report an 8-year-old girl with a previous clinical diagnosis of chronic active Epstein–Barr virus inf...

Single-cell and spatial transcriptomics reveal glycolytic remodeling and ENO1-associated metabolic vulnerability in hepatoblastoma

Hepatoblastoma (HB) is the most common malignant liver tumor in children; however, the contribution of glycolytic metabolic reprogramming to HB development and progression remains incompletely characterized. We integrated single-cell RNA sequencing and spatial transcriptomic data...

Uncovering the microbiota-metabolite axis across levels of metabolic complication burden in Chinese adolescents with obesity

Pediatric obesity presents with diverse metabolic phenotypes, yet the gut microbiota and metabolite signatures associated with obesity-related metabolic complications remain poorly defined. Here, we applied 16S rRNA gene sequencing and untargeted fecal metabolomics to investigate...

Measurable residual disease detected by next-generation sequencing in T-cell acute lymphoblastic leukemia

The clinical utility of measurable residual disease monitoring based on next-generation sequencing in T-cell acute lymphoblastic leukemia remains incompletely defined. Here we show the prognostic value of tracking clonal T-cell receptor gene rearrangements by next-generation sequ...

Nickase-based suppression of self-ligation in long sticky-end adapters for next-generation sequencing library preparation

The correctness and efficiency of the adapter connection are important factors affecting the quality and yield of the libraries in next-generation sequencing (NGS). Lengthening the sticky ends of the adapters and the targets can effectively improve the efficiency of ligation, how...

Subcutaneous Belimumab Demonstrates Consistent Steady-State Pharmacokinetics and is Well Tolerated in Paediatric Patients with SLE in China: An Open-Label Study

This study assessed pharmacokinetics and safety of subcutaneous (SC) belimumab in Chinese paediatric patients with systemic lupus erythematosus (cSLE) who previously received intravenous (IV) belimumab; only the IV form is approved for cSLE in China. This single-arm, open-label,...

Effect of postpartum probiotic supplementation on breastmilk composition and infant health: a pilot randomized controlled trial

Breast milk is the optimal infant nutrition, and its composition is influenced by maternal factors including supplement intake. This study aimed to investigate the effects of postpartum probiotic supplementation on breast milk composition and infant health outcomes. This double-b...