Children's Hospital of Pittsburgh

Improving Discharge Instructions: Systematic Review of Language and Health Literacy Interventions.

CONTEXT: Effective pediatric inpatient discharge relies on clear, responsive communication to support safe transitions from hospital to home. Families who use a language other than English and those with lower health literacy experience disproportionate barriers during discharge,...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

Experimental versus clinical studies capture distinct types of relapse in tuberculosis

(Mtb) currently infects a quarter of the world's population. Though many TB patients cure infection with short-course treatment, regimens shorter than 4 months risk post-treatment relapse. This is facilitated by the presence of granulomas, spatially heterogeneous immune structure...

Biliary complications in pediatric living donor liver transplantation: An international multicenter analysis of risk and prognostic factors

Biliary reconstruction is often considered the Achilles’ heel of liver transplantation, yet risk factors and outcomes remain poorly defined, particularly in pediatric living donor liver transplantation (LDLT). This international multicenter study aims to identify predictors of bi...

Evaluation of a National Mentorship Pilot Program for Early-Career Women in PHM

BACKGROUND: Women comprise most of the pediatric hospital medicine (PHM) workforce yet experience disparities in authorship, leadership, and compensation. Structured mentorship and professional development tailored to early-career women remain limited. Supporting Her in Navigatin...

Postoperative outcomes and predictors of functional sequelae following hemispheric surgery in Rasmussen's encephalitis: A retrospective cohort study from the global pediatric epilepsy surgery registry

Abstract Objective Rasmussen's encephalitis (RE) is a rare and progressive, immune‐mediated epileptic encephalopathy characterized by drug‐resistant seizures and neurological decline. While hemispheric disconnection (HD) is the gold standard treatment for effective seizure contro...

Sociodemographic and Clinical Factors Associated With Nirsevimab Receipt Among Children Aged Younger Than 20 Months in the New Vaccine Surveillance Network in 2023 to 2025

OBJECTIVES: We aim to evaluate the association of sociodemographic and clinical factors with nirsevimab receipt among children with medically attended acute respiratory illness (ARI) across multiple seasons and beyond birth hospitalization. PATIENTS AND METHODS: We included nirse...

Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI): an international study

Juvenile localised scleroderma (jLS) is a rare disease which impacts negatively on health-related quality of life (HRQoL). We aimed to undertake the cross-cultural adaptation and validation of a novel disease-specific HRQoL measure, the Localised Scleroderma Quality of Life Instr...

Pathogens in the Nasopharynx Before and After Antibiotic Treatment for Acute Otitis Media

BACKGROUND: Limited data exist on whether the timing or duration of treatment for acute otitis media (AOM) affects nasopharyngeal carriage. We studied the eradication of pathogens (Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis) in relation to timing (...