Children's Hospital of Michigan

Ceftaroline Diffusion Into Cerebrospinal Fluid of Children With Ventriculitis Due to Ventriculoperitoneal Shunt Infection

BACKGROUND: Data on ceftaroline cerebrospinal fluid (CSF) levels in children are limited. This study examined ceftaroline diffusion into CSF among children with ventriculoperitoneal shunt (VPS)-related ventriculitis and external ventricular drains. METHODS: Patients received a si...

Accidental Toxicological Pediatric Ingestions: Disparities in the Involvement of Social Work and Child Protective Services

OBJECTIVES: To examine sociodemographic and clinical factors associated with social work consultation and child protective services (CPS) referrals among children presenting to the pediatric emergency department (ED) after an accidental toxicological ingestion. METHODS: This retr...

Interplay between fibroblast growth factor 9 (FGF9) and CD44 underlies 46,XY disorders of sex development in Kruppel‐like factor 1 (KLF‐1)‐E325K‐associated congenital dyserythropoietic anaemia (CDA‐IV)

Summary A heterozygous Kruppel‐like factor 1 (KLF1) E325K mutation causes a severe form of congenital dyserythropoietic anaemia (CDA), designated CDA‐IV (Online Mendelian Inheritence in Man, OMIM 613673), a rare disease with only 15 cases known. In addition to haemolytic anaemia,...

Futility and Termination of Resuscitation Variation for Pediatric Out-of-Hospital Cardiac Arrest

OBJECTIVES To evaluate agency-level differences in determinations of futility (defined as withholding resuscitative efforts by emergency medical services [EMS]) and termination of resuscitation (TOR) during prehospital encounters for pediatric out-of-hospital cardiac arrest (OHCA...

Cord Blood DNA Methylation and Large-for-Gestational-Age Birth: A Pilot Epigenome-Wide Study in the GROW Cohort

Background/Objectives: Large-for-gestational-age (LGA) birth is associated with adverse perinatal outcomes and increased risk of metabolic disease later in life. Despite these risks, epigenetic studies of LGA remain limited, particularly those using umbilical cord blood DNA methy...

Beating the Odds: Successful Thrombectomy Followed By Heart Transplant in a Pediatric Ventricular Assist Device Patient

Ventricular assist devices (VADs) are increasingly used in pediatric patients with end-stage heart failure as a bridge to heart transplantation (HT). Thromboembolic stroke remains one of the most devastating complications and may jeopardize transplant candidacy. We report a 13-ye...