Children's Hospital of Los Angeles

Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants

BACKGROUND: High-risk infants with significant neonatal-perinatal morbidities often require opioids, but prolonged exposures can impair neurodevelopment. We evaluated the effect of cumulative opioid exposures in the first year of life, measured by morphine milligrams equivalents...

High-Value Care in Pediatric Critical Care: Intravenous to Enteral Gastrointestinal Medications

Advancing pediatric critical care medicine includes identifying and reducing health care costs while maintaining—and even enhancing—the delivery of high-value care. Gastrointestinal (GI) prophylaxis (PPX) is commonly prescribed for children in the pediatric intensive care unit (P...

Efficacy and Safety of Time-Restricted Eating in Adults With Type 1 Diabetes: A Randomized Controlled Trial

OBJECTIVE: Many adults with type 1 diabetes (T1D) have overweight or obesity, underscoring the need for effective dietary weight loss strategies in this population. Time-restricted eating (TRE) has emerged as a popular approach for weight loss; however, its efficacy and safety in...

Wnt Pathway Agonism as a Therapeutic Strategy for Retinal Vascular Diseases: A Narrative Review of Evidence to Date

Breakdown of the blood–retinal barrier (BRB) is implicated in many blinding retinal diseases, including diabetic macular edema, neovascular age-related macular degeneration, and retinal vein occlusion. Anti-vascular endothelial growth factor (anti-VEGF) therapies or laser photoco...

Postoperative Interventions and Cost Associated With Disposition After Tonsil and Adenoidectomy

OBJECTIVE To evaluate postoperative disposition and resource use among patients admitted to the inpatient unit or pediatric intensive care unit (PICU) following tonsillectomy, adenoidectomy, and tonsillectomy/adenoidectomy (T/A). PATIENTS AND METHODS This retrospective cohort stu...

Safety and Tolerability of Chronic Carvedilol in Pediatric Dilated Cardiomyopathy: A Report from the Pediatric Cardiomyopathy Registry

Long-term studies on safety of beta-blockers in pediatric heart failure (HF) are scant. We describe the safety profile, dose ranges, and tolerability of carvedilol in pediatric dilated cardiomyopathy (DCM). The Pediatric Cardiomyopathy Registry (PCMR) was used to identify patient...

Parents of youth and young adults with intellectual and developmental disabilities: Barriers experienced during transition

PurposeThe purpose of this study was to explore the experiences of parents of youth and young adults with intellectual and developmental disabilities who have undergone the transition from pediatric to adult healthcare as well as community-based transition and adult-focused servi...

Maternal immune activation disrupts the kynurenine pathway of tryptophan metabolism in the placenta–fetal brain axis in rats

Abstract Background Maternal immune activation is a major risk factor for neurodevelopmental disorders; however, the molecular mechanisms linking gestational inflammation to fetal brain vulnerability remain incompletely defined. The tryptophan–kynurenine pathway is highly respons...

Disparities in Hospital Length of Stay and Morbidity in Acute Care Pediatric Cardiology Patients

BACKGROUND Multicenter collaborative studies examining disparities in in-hospital outcomes are lacking in pediatric cardiology. We hypothesized that Black and Hispanic patients in pediatric acute care cardiology units (ACCUs) have increased length of stay (LOS) and complications...

Top 10 Tips Palliative Care Clinicians Should Know About Preventing Burnout

Health care worker burnout is a potential job hazard. Palliative care clinicians (PCCs) are especially vulnerable due to the intense emotional and challenging demands of the work. Creating environments for PCCs to thrive is the responsibility of the organization, however, PCCs ha...