Children's Hospital of Chongqing Medical University

tiRNA-Pro-AGG-001 serves as a host-directed prognostic biomarker and therapeutical target for pediatric sepsis

Pediatric sepsis and septic shock remain major causes of mortality in Children, yet robust, mechanistically anchored biomarkers for severity stratification are limited. We profiled plasma tRNA-derived small RNAs (tsRNAs) in children with sepsis and septic shock, and validated can...

Behavioral and electrophysiological characteristics of auditory atypicalities in children with autism spectrum disorder

Sensory atypicalities, particularly auditory, are highly prevalent in children with autism spectrum disorder (ASD). Objective electrophysiological indices for characterizing these differences are lacking. Mismatch Negativity (MMN) reflects automatic auditory processing at the pre...

Associations between hypertensive diseases of pregnancy and birthweight outcomes in twin pregnancies: A large‐scale retrospective cohort study

OBJECTIVE: This study aimed to assess the association between hypertensive disorders of pregnancy (HDPs) and birthweight outcomes in twin pregnancies, an area that remains underexplored compared to the well-documented short- and long-term effects of HDPs in singleton pregnancies....

Gestational Changes in Placental Iron Homeostasis are Associated With Ferroptosis‐Associated Redox Signaling and Trophoblast Behavior

Well-regulated trophoblast proliferation, migration, invasion, and cell turnover are essential for normal placental development in humans and rodents. Given the established role of oxidative stress in placentation and the redox activity of iron, we investigated whether ferroptosi...

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

ABSTRACT Joint profiling of chromatin accessibility and gene expression in the same cell enables direct linkage of regulatory elements to transcriptional output, but existing approaches remain limited by low co‐capture sensitivity, proprietary platforms, and high costs. Here we p...

Association between carbohydrate-to-fiber ratio and endometriosis in U.S. women: mediating role of neutrophil-percentage-to-albumin ratio

Objectives Associations between carbohydrate and fiber intake and endometriosis (EM) have been inconsistent, and no study has evaluated the combined effect of the carbohydrate-to-fiber ratio (CFR) or its inflammatory mechanisms.Materials and Methods TThis cross-sectional study us...

Effect of refractive correction of myopia on health-related quality of life among children aged 3–12 years: a prospective observational cohort study

To analyze refractive changes and health-related quality of life (QOL) in children with myopia aged 3–12 years and to explore the effects of refractive correction on the QOL of children in different age groups and their parents. A 1-year prospective cohort study was conducted wit...

Exposure to chemotherapy alters secondary drug sensitivity without genomic alterations in patient-derived ovarian cancer organoid models

Ovarian cancer has significant morbidity and mortality due to high rates of resistance to chemotherapy and recurrence. Our objective was to deploy patient-derived organoid (PDO) models of ovarian cancer to assess secondary drug sensitivity after exposure to chemotherapy in vitro....

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Predicting relapse risk in first episode psychosis using machine learning and sleep data

Abstract Sleep disturbance is common in First Episode Psychosis (FEP) and is associated with psychosis symptom exacerbation and functional decline, yet it remains unclear which sleep features predict relapse. In this longitudinal study, 269 FEP participants reported daily sleep d...

The Correlates of Recoarctation After Repair in Pediatric Patients with Aortic Coarctation: A Real-World Descriptive Study

Background/Objectives: This retrospective descriptive real-world study aimed to characterize clinical features and factors associated with recoarctation in children with coarctation of the aorta (CoA) and develop a composite metric to quantify postoperative residual aortic obstru...

β3GnT2-mediated N-glycosylation of EGFR and LDLR drives glioblastoma progression and can be targeted by AST-1306

Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by a poor prognosis and limited therapeutic options. In this study, we identify β3GnT2 (β-1,3-N-acetylglucosaminyltransferase 2) as a critical driver of GBM progression and a potential therapeut...

Differential efficacy and safety of ruxolitinib in primary versus secondary hemophagocytic lymphohistiocytosis: a systematic review and meta-analysis

Ruxolitinib (RUX), a JAK1/JAK2 inhibitor, has demonstrated therapeutic potential in both primary and secondary hemophagocytic lymphohistiocytosis (pHLH & sHLH), but quantitative evidence comparing its efficacy and safety across subtypes remains lacking. Given the absence of rando...

Primary anastomosis versus staged enterostomy for post-necrotizing enterocolitis intestinal stricture in infants: a propensity score-matched cohort study and prediction model

Post-necrotizing enterocolitis (NEC) intestinal stricture is an important late complication among NEC survivors. Surgical management commonly involves primary anastomosis (PA) or staged enterostomy (SE), but comparative evidence in this population remains limited. We compared pos...

Initial response and long-term prognostic risk factors in pediatric ITP

To explore the clinical features and prognostic factors for initial response and long-term prognosis of pediatric immune thrombocytopenia (ITP). A retrospective cohort study of 910 cases of pediatric patients with ITP was conducted. Demographic data, platelet counts, triggers, bl...

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease, with podocyte injury driving disease progression. Mitochondrial dysfunction and ferroptosis contribute to podocyte loss, yet the underlying molecular mechanisms remain incompletely understood. The anti-a...

PIGU expression is associated with poor prognosis and estimated immune cell infiltration in breast invasive carcinoma

Breast invasive carcinoma (BRCA) is a major cause of cancer-related mortality in women. PIGU , a subunit of the GPI-anchor biosynthesis complex, has been reported to be dysregulated in several cancers; however, its prognostic value and immune-related associations in BRCA remain u...

RPPH1 drives ovarian cancer cells proliferation via CDK9-c-Myc axis

Dysregulation of the proto-oncogene c-Myc is a critical driver of ovarian cancer progression, yet the mechanisms governing its expression remain incompletely characterized. A systematic bioinformatic analysis was used to screen long non-coding RNA involved in the regulation of c-...

A single-nucleus transcriptomic characterization of EGFR G719X/S768I double-mutant lung adenocarcinoma identifies an immunosuppressive niche defined by COL4A3-CD44 interaction

EGFR double mutations (G719X/S768I) represent a clinically recalcitrant subtype of lung adenocarcinoma (LUAD) characterized by diminished tyrosine kinase inhibitor (TKI) sensitivity. However, the specific tumor microenvironment (TME) features and intercelluar crosstalk driving th...