Children's Hospital at Westmead

Anesthesia as a Partner in Public Health: Enabling National Pediatric SARS-CoV-2 Serosurveillance in Australia

Anesthetic departments played a critical role in Australia’s COVID-19 response by facilitating the collection of residual blood samples from children undergoing elective procedures. Through a partnership with the Pediatric Active Enhanced Disease Surveillance network, this approa...

Rehabilitation management of children with hereditary spastic paraplegia: a retrospective cohort study

Background Hereditary spastic paraplegia (HSP) is a group of rare, genetically heterogeneous neurodegenerative conditions characterized by progressive lower limb spasticity. In children, rehabilitation management of HSP is commonly extrapolated from cerebral palsy practice, despi...

Corticosteroid use in children with community acquired sepsis: a multicentre prospective cohort study

Objectives Corticosteroids in paediatric sepsis have the potential to improve outcomes, yet there is little supporting evidence regarding efficacy, choice of agents, dose or timing of administration. We describe the patterns of corticosteroid use in children hospitalised with sus...

Growing old before growing up

Frailty is a condition commonly associated with aging, characterized by functional and cognitive decline, increasing dependence, and early mortality, but it is rarely conceptualized in children. We present a caregivers' perspective on frailty in her daughter living with childhood...

Expanding the genotypic and phenotypic spectrum of PGAP1 deficiency: clinical and functional insights from 15 patients

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are essential for neuronal development, synaptic organization and signaling. Defects in GPI-anchor biosynthesis or remodeling cause rare neurodevelopmental disorders, including post-GPI attachment to proteins 1 (PGAP1) defi...

ANZTCT cytomegalovirus practice survey for allogeneic haemopoietic stem cell transplant and cellular therapy recipients in Australia and New Zealand

BACKGROUND: Despite pre-emptive treatment (PeT), cytomegalovirus (CMV) disease and reactivation remain a clinical concern. In Australia and New Zealand (ANZ), variability exists in the management of CMV for haematopoietic stem cell transplantation (HSCT) recipients. AIMS AND METH...

Implementing a patient decision aid about selective dorsal rhizotomy in clinical practice: pre-post pilot study

PURPOSE: To evaluate whether implementing a patient decision aid about Selective Dorsal Rhizotomy (SDR) for carers of children with bilateral spastic cerebral palsy (CP) improves carer decision-making outcomes and is acceptable to healthcare providers, and to explore carers' expe...

Potential Neonatal Donors in Australia: A National Cohort Study

BACKGROUND AND OBJECTIVE: Neonatal organ donation could significantly expand the deceased donor pool, but referral pathways and acceptance criteria remain highly variable worldwide and determination of neurological death in neonatal patients has traditionally been considered chal...

Following the rules: which type 1 diabetes guidelines, protocols and recommendations are tertiary clinics in Australia following? A quantitative study

OBJECTIVES: This study characterises the use of type 1 diabetes (T1D) guidelines and protocols in Australian T1D clinics working with paediatric patients, and determines if management practices align with T1D-specific guidelines. METHODS: T1D clinic service leaders responded to a...

Outcomes following dialysis and transplantation in amyloidosis: ANZDATA analysis

Abstract Background The kidneys are frequently affected by systemic amyloidosis. Despite this, contemporary survival outcomes for patients reaching kidney failure due to amyloidosis remain poorly defined relative to other causes of kidney failure. This study aims to characterise...