Children Cancer Hospital

Globalising the access to advanced molecular diagnostics of CNS tumors: Experience of the Molecular Neuro-Pathology (MNP) Outreach Consortium

Central nervous system (CNS) tumors pose a major global health challenge, particularly in low- and middle-income countries (LMICs), where outcomes remain disproportionately poor. The global CONCORD-3 study (Lancet Oncology) highlighted stark disparities in five-year survival (201...

Mechanistic attenuation by L-carnitine of trastuzumab-induced downregulation of adenosine monophosphate -activated protein kinase signal in cardiac H9c2 cells

Clinical usefulness of trastuzumab (TZ) is restrained owing to its cardiotoxic effect. This investigation was initiated to evaluate the potential protective impact of carnitine (CARN) against TZ-related cardiac influence; and to uncover the underlining mechanism. Cytotoxic effect...

A Prognostic Score for Predicting 30-Day Mortality After Gram negative Bloodstream Infection in Pediatric Patients with Hematological Malignancy

Abstract Background Patients with hematological malignancies (HMs) are at high risk of gram-negative bloodstream infections (GN-BSI) due to prolonged immunosuppression and neutropenia. These infections are associated with significant morbidity and mortality, often exceeding 30%....

Cyberknife radiosurgery for hemifacial spasm

Background: Surgical management of hemifacial spasm (HFS) may be contraindicated in medically unfit patients or declined because of the potential risks associated with surgery. Therefore, minimally invasive and non-invasive alternatives merit investigation. This preliminary study...

plsMD: a plasmid reconstruction tool from short-read assemblies

Abstract Background While whole genome sequencing has become a cornerstone of antimicrobial resistance surveillance, the reconstruction of plasmid sequences from short-read data remains a challenge due to repetitive sequences and assembly fragmentation. Current computational tool...