Chifeng Municipal Hospital

Association between respiratory phenotypes and successful ventilator liberation in early-onset and late-onset ARDS: a multicenter cohort study

Early-onset and late-onset acute respiratory distress syndrome (ARDS) differ in clinical course and outcomes, but their longitudinal respiratory trajectories remain unclear. We aimed to characterize respiratory trajectories in early- and late-onset ARDS and identify trajectory-ba...

Exploratory thyroid ultrasound–computed tomography synthesis using anatomy-preserving contrastive unpaired translation

OBJECTIVES: When ultrasound (US) and computed tomography (CT) are both clinically indicated, unpaired image translation may support model development but cannot replace either examination. We evaluated Anatomy-Preserving Contrastive Unpaired Translation (AP-CUT), a CUT-based fram...

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

The value of combined SATB2 and CDX2 detection in the differential diagnosis of colorectal adenocarcinoma

This study evaluates the diagnostic value of SATB2 and CDX2, used individually and in combination, in the immunohistochemical differential diagnosis of colorectal adenocarcinoma. A retrospective case-control diagnostic accuracy study was conducted, including 122 patients with his...

Gut microbiota‑driven indole‑3‑propionic acid protects against sepsis‑associated encephalopathy via inhibiting BNIP3L ubiquitination and restoring BNIP3L‑dependent mitophagy as a potential molecular mechanism

Sepsis-associated encephalopathy (SAE) is a severe refractory neurological complication occurring in up to 70% sepsis patients with no targeted therapies. Gut microbiota-derived indole-3-propionic acid (IPA), a tryptophan metabolite, exerts neuroprotective effects, but its therap...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...