Chicago State University

Daraxonrasib and the heart: cardiovascular implications of the first clinically successful pan-RAS(ON) inhibitor

Daraxonrasib (RMC-6236), the first orally bioavailable pan-RAS(ON) inhibitor, produced a significant survival benefit in the Phase 3 RASolute 302 trial in previously treated metastatic pancreatic ductal adenocarcinoma (PDAC), reducing the risk of death by 60% versus chemotherapy...

Metformin Spacer Conformation Is a Structure-Directing Element in a 2D Perovskite with Strong X-ray Response

Abstract Direct X-ray detection in two-dimensional (2D) hybrid metal-halide perovskites is dictated by the interplay between organic spacer chemistry, crystal structure, and charge transport. Among these materials, the metformin (MF2+)-based perovskite MFPbI4 has recently emerged...

Pooled prevalence of anxiety and depressive symptoms among adults with type 2 diabetes: a systematic review and meta-analysis

Abstract Purpose Anxiety and depressive symptoms are highly prevalent among individuals with type 2 diabetes mellitus (T2DM), yet they remain underdiagnosed despite their substantial impact on health outcomes. In addition to impairing treatment adherence, these conditions may con...