Chia Nan University of Pharmacy and Science

Sodium-glucose cotransporter-2 inhibitors, severe sepsis, and infection-related outcomes in patients with chronic kidney disease and type 2 diabetes

Background: Patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) are vulnerable to infections. While sodium-glucose cotransporter-2 (SGLT-2) inhibitors provide established cardiorenal benefits, their effects on infection remain unclear. This study aimed to evaluat...

Severe Dengue in Children: Pathogenesis, Early Recognition, and Evidence-Informed Management

Severe dengue remains an important cause of pediatric hospitalization, morbidity, and mortality in tropical and subtropical regions, particularly where rapid triage and pediatric critical-care capacity are limited. This structured narrative review synthesizes evidence on the epid...

Association Between Bladder Management Strategies and Symptomatic Urinary Tract Infections in Patients with Chronic Spinal Cord Injury: Lessons from a 5-Year Longitudinal Cohort

Background: Urinary tract infections (UTIs) are a leading cause of morbidity in patients with chronic spinal cord injury (SCI). This study examined the incidence of first and recurrent symptomatic UTIs in patients with chronic SCI and explored clinical factors associated with inf...

Developmentof Noval, Recyclable, and Tunable ArylImidazolium Salts with a Dual Brønsted–Lewis Acid Characteras Catalysts for the Copper(I)-Catalyzed Azide–Alkyne CycloadditionReaction (CuAAC)

Abstract The development of novel aryl imidazolium salts (ISs) with dual Brønsted–Lewis acid character represents a significant advancement in the field of green chemistry and catalysis. These imidazolium salts serve as efficient catalysts for the copper(I)-catalyzed azide–alkyne...

Development ofa Shapley Additive Explanations (SHAP)-InterpretableModel for Cardiovascular Risk Stratification in Type 2 Diabetes Mellitus:Implications of MDA-Modified Protein Adducts and Autoantibodies

Abstract Coronary artery disease (CAD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). This study explores the two-hit oxidative–immune hypothesis by evaluating malondialdehyde (MDA)-modified protein (MDA-protein) adducts and their corresponding autoantibodi...

Evaluation and application of iron-modified clay adsorbents for clean fuel production in the frame of desulfurization technology

Abstract This study investigated clay adsorbents for benzothiophene sulfone (BTO) removal through oxidative desulfurization. Bentonite-Fe 3+ (BF3), Fe 6+ (BF6), activated clay-Fe 3+ (ACF3), and Fe 6+ (ACF6) were synthesized via impregnation of raw bentonite (BR) and raw activated...