Chi Mei Medical Center

Diagnostic challenges posed by the wide morphological and immunophenotypic spectrum of plasma cell neoplasms

Plasma cell neoplasms (PCNs) are a group of malignant neoplasms originating from the monoclonal expansion of immunoglobulin-secreting, terminally differentiated B cells, i.e., plasma cells (PCs). PCNs include monoclonal gammopathy of undetermined significance (MGUS), plasmacytoma...

Mixture-of-prompt experts for federated sentiment classification under non-IID data

Federated learning (FL) enables collaborative text classification while preserving data privacy, yet its performance can be degraded under non-IID data. This challenge is particularly severe in natural language processing, where client data may differ in linguistic style, topic d...

Sodium-glucose cotransporter-2 inhibitors, severe sepsis, and infection-related outcomes in patients with chronic kidney disease and type 2 diabetes

Background: Patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) are vulnerable to infections. While sodium-glucose cotransporter-2 (SGLT-2) inhibitors provide established cardiorenal benefits, their effects on infection remain unclear. This study aimed to evaluat...

Severe Dengue in Children: Pathogenesis, Early Recognition, and Evidence-Informed Management

Severe dengue remains an important cause of pediatric hospitalization, morbidity, and mortality in tropical and subtropical regions, particularly where rapid triage and pediatric critical-care capacity are limited. This structured narrative review synthesizes evidence on the epid...

Necrotising enterocolitis triggers a TNF-driven gut-blood-brain cascade that disrupts the blood-brain barrier and induces TNFR1-skewed neuronal apoptosis and pyroptosis

Necrotising enterocolitis (NEC) in very-low-birthweight (VLBW) infants is associated with neurodevelopmental difficulties, but the mechanisms linking intestinal disease to brain injury remain unclear. We asked whether NEC propagates along a tumour necrosis factor alpha (TNF-α)-ce...

Tirzepatide Use Is Associated with Reduced Risk of Carpal Tunnel Syndrome in Overweight and Obese Adults

This study aimed to evaluate the association between tirzepatide use and the risk of carpal tunnel syndrome (CTS) and CTS surgery compared with both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and other anti-obesity medications in individuals who are overweight or obese....

Long-Term Corticosteroid-Induced Ocular Hypertension Model Produced by Topical Rinderon-A Ointment Application

Adverse effects associated with prolonged corticosteroid therapy are strongly associated with increased intraocular pressure (IOP), which may progress to iatrogenic glaucoma and irreversible blindness if left untreated. Developing reliable animal models is essential for investiga...