Chi Mei Medical Center

Necrotising enterocolitis triggers a TNF-driven gut-blood-brain cascade that disrupts the blood-brain barrier and induces TNFR1-skewed neuronal apoptosis and pyroptosis

Necrotising enterocolitis (NEC) in very-low-birthweight (VLBW) infants is associated with neurodevelopmental difficulties, but the mechanisms linking intestinal disease to brain injury remain unclear. We asked whether NEC propagates along a tumour necrosis factor alpha (TNF-α)-ce...

Tirzepatide Use Is Associated with Reduced Risk of Carpal Tunnel Syndrome in Overweight and Obese Adults

This study aimed to evaluate the association between tirzepatide use and the risk of carpal tunnel syndrome (CTS) and CTS surgery compared with both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and other anti-obesity medications in individuals who are overweight or obese....

Long-Term Corticosteroid-Induced Ocular Hypertension Model Produced by Topical Rinderon-A Ointment Application

Adverse effects associated with prolonged corticosteroid therapy are strongly associated with increased intraocular pressure (IOP), which may progress to iatrogenic glaucoma and irreversible blindness if left untreated. Developing reliable animal models is essential for investiga...