Chengdu Women's and Children's Central Hospital

Pediatric and adolescent fallopian tube torsion: diagnosis and management in a case series of five precoitarchal patients

Pediatric and adolescent fallopian tube torsion, whether isolated or accompanied by ovarian torsion, is a rare gynecologic surgical emergency in which the diagnosis is frequently delayed due to nonspecific symptoms, threatening patients’ fertility. Early identification of fallopi...

Lactylation as a potential epigenetic and metabolic modulator of cuproptosis in health and disease: Current evidence and hypotheses

As a lactate-derived post-translational modification, lactylation plays a vital role in connecting cellular glycolysis with the regulation of cuproptosis, a unique form of cell death triggered by copper overload. The article explores the growing relationship between lactylation a...

Genetic risk factors and causal associations with sudden cardiac arrest

Sudden cardiac arrest (SCA) is a major cause of mortality, with complex etiology involving multiple genetic and environmental factors. In this study, we aimed to identify genetic risk factors for SCA and evaluate their causal associations using Mendelian randomization (MR) analys...

Evolution and paradigms in ion channel and cardiac remodeling

Objective: This study aims to conduct a bibliometric analysis of the literature on the role of ion channels in cardiac remodeling. Methods: Articles on ion channels and cardiac remodeling from 1979 to 2024 were retrieved from the Web of Science Core Collection (WoSCC). Bibliometr...

Extraventricular neurocytomas stratified by tumor location and histological subtype: clinical features, radiology, pathology, and prognosis

Abstract Objective To compare the differences in clinical manifestations, imaging features, histological characteristics, and prognostic outcomes of extraventricular neurocytomas (EVNs) based on tumor location (parenchymal vs. sellar) and histological subtype (typical vs. atypica...

The IER5L–AK2 axis drives aggressive behavior in triple-negative breast cancer

Breast cancer is the most frequently diagnosed malignancy in women worldwide. Triple-negative breast cancer (TNBC) has particularly poor outcomes, largely due to the lack of effective therapeutic targets. Here, we investigated the expression pattern, functional relevance, and pot...

Impact of inoculation of inactivated COVID-19 vaccine on the outcomes of frozen-thawed embryo transfer

Abstract To assess the impact of inoculation of inactivated corona virus disease 2019 (COVID-19) vaccine on the outcome of frozen-thawed embryo transfer (FET). From January 2022 to November 2023, patients aged 20 ~ 45 years old undergoing FET at the Reproductive Medicine Center o...

Laparoscopic management of isolated fallopian tube torsion in the second trimester: a case report

Abstract Background Isolated fallopian tube torsion is a rare gynecological acute abdomen. Its clinical manifestations and imaging findings are non-specific, making preoperative diagnosis relatively challenging. Isolated fallopian tube torsion during pregnancy is even rarer, as t...

Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma

Tumour-associated macrophages (TAMs) are known to promote tumour progression in many kinds of malignant tumour, including hepatoblastoma (HB). Based on previous studies, we suggested that TAM-mediated sex-determining region Y-box 9 (SOX9) signal might enhance HB progression. The...

Molecular identification of Hypoderma sinense cutaneous myiasis in a child from a cattle-raising pastoral region of China: a case report

Abstract Background Zoonotic parasitic infestations may be overlooked when they mimic common pediatric skin infections. Cutaneous myiasis caused by Hypoderma species is mainly associated with livestock, whereas human infestation by Hypoderma sinense ( H. sinense ) is rarely repor...