Chengdu Second People's Hospital

Stage-specific nanotherapeutics for glaucoma target elevated IOP, impaired aqueous-humor outflow, RGC degeneration, and fibrotic inflammation during postoperative wound healing

Glaucoma is a chronic neurodegenerative disease in which elevated intraocular pressure (IOP), impaired aqueous-humor outflow, retinal ganglion cell (RGC) degeneration, and postoperative fibrosis may coexist or predominate at different stages. Conventional therapies are effective...

Circulating Protein Biomarkers for Primary Cardiomyopathy: Evidence from Mendelian Randomization and Clinical Validation

BACKGROUND: Primary (non-ischemic) cardiomyopathy poses diagnostic challenges due to phenotypic heterogeneity and non-specific clinical presentation, and commonly used circulating biomarkers have limited disease specificity. The aim was to prioritize mechanism-informed plasma bio...

Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial

Traditional antifungal therapy for Malassezia folliculitis (MF) is often associated with high recurrence rates and limited long-term options. This study evaluated the efficacy and safety of 30% supramolecular salicylic acid (SSA) combined with supramolecular active zinc (SAZ) in...

Integrative identification and preliminary validation of senescence-associated secretory phenotype-related candidate biomarkers in type 2 diabetes

Senescence-associated secretory phenotype (SASP)-related inflammatory programs have been implicated in type 2 diabetes mellitus (T2DM), yet blood-based candidates have not been systematically screened and validated across independent cohorts. We adopted standardized senescence si...

Factors associated with role strain among male nursing students: Insights from stress-coping and stress-buffering frameworks

Background Men remain markedly underrepresented in the global nursing workforce, and male nursing students frequently encounter gender stereotypes, limited clinical opportunities, and inadequate professional support during their training. These gender-related experiences may hind...

Extraventricular neurocytomas stratified by tumor location and histological subtype: clinical features, radiology, pathology, and prognosis

Abstract Objective To compare the differences in clinical manifestations, imaging features, histological characteristics, and prognostic outcomes of extraventricular neurocytomas (EVNs) based on tumor location (parenchymal vs. sellar) and histological subtype (typical vs. atypica...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Risk factors for surgical site infection after internal fixation for thoracolumbar fractures

The purpose of this study was to investigate the risk factors for surgical site infection (SSI) after internal fixation by posterior approach in patients with thoracolumbar fractures. According to whether SSI occurred after internal fixation, patients were divided into SSI group...

Latent profile analysis of social alienation and its influencing factors in patients undergoing maintenance hemodialysis

Social alienation severely impairs the mental health and quality of life of patients undergoing maintenance hemodialysis (MHD). However, most studies conducted have been variable-centered, group-level analyses, which cannot capture inherent heterogeneity in social alienation, hin...

Causal association between air pollution and functional outcome after ischemic stroke: Evidence from 2-sample MR study

Observational studies have shown that air pollution may affect functional outcome following ischemic stroke. Our study aimed to explore the relationship between genetically predicted specific air pollutants and poststroke functional outcomes using the Mendelian randomization (MR)...

Research on the dynamic evolution of competitive and water-film-mediated wear mechanisms of the carbon strips in the pantograph-catenary system at low temperature

Abstract To investigate the evolution of wear mechanisms in carbon strips at low temperature, this study conducted comparative friction tests on copper-impregnated carbon strips at room temperature (25 °C) and low temperature (-20 °C). To replicate operating conditions, the exper...