Chengdu Military General Hospital

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8

Abstract Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour–stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage polarization, the precise m...