Chengdu Military General Hospital

Overcoming diagnostic pitfalls of Haemophilus influenzae type b frontal osteomyelitis: a systematic review plus index-case analysis in the post-vaccination era

Invasive Haemophilus influenzae type b (Hib) infections have become exceedingly rare in adults following universal childhood vaccination. This decline poses a diagnostic challenge, as clinical suspicion and laboratory protocols may not be optimized for its detection. To systemati...

Dynamic association between gut microbiota succession and host metabolism: differential effects of antibiotic intervention duration on glucose and lipid metabolism in high-fat diet-induced obese mice

Abstract Background The gut microbiota plays a critical role in the onset and progression of obesity. Previous studies have indicated that antibiotic administration may influence host physiology and pathology by modulating the gut microbiota. However, whether different durations...

Occurrence levels of alexithymia in clinical nurses: a systematic review and meta-analysis

Abstract Background Nursing is a profession that involves providing comprehensive care through continuous interactions and reciprocal relationships with patients. Alexithymia among nurses may impair effective nurse–patient communication and interaction. It may not only compromise...

Tertiary lymphoid structures in cancer: their development, composition, clinical prognosis, and the drivers of the anti-tumor responses

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates formed under chronic inflammatory tumor microenvironments. Clinical cohorts across solid cancers demonstrate that mature TLS with intact germinal centers serve as independent favorable prognostic biomarkers and pr...

Latent profiles and influencing factors of missed nursing care among ICU nurses

Abstract Background Missed nursing care (MNC) is common in intensive care units (ICUs) and seriously threatens patient safety. Most existing studies treat ICU nurses as a homogeneous group, overlooking within-group heterogeneity. Based on the Job Demands-Resources model, this stu...

A Novel Preclinical Rat Model of Acute Compartment Syndrome

Acute compartment syndrome (ACS) is common in trauma, challenging early diagnosis and treatment. An accurate ACS model is vital for its management. Most prior animal models have induced intrafascial hypertension by exogenous interventions, focusing on the study of secondary injur...

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8

Abstract Lung cancer bone metastasis carries a poor prognosis, yet the metabolic determinants driving tumour–stroma crosstalk remain largely elusive. Despite extensive investigations into itaconate, a prominent immunometabolite implicated in macrophage polarization, the precise m...