Chengdu Fifth People's Hospital

Ecosocial environments and chronic lower respiratory disease mortality: a nationwide ecological study

Chronic lower respiratory disease (CLRD) is a leading cause of death in the United States and imposes a substantial economic burden. Ecosocial environments are closely linked to population health, yet nationwide evidence on their associations with CLRD mortality remains limited....

Association between ticagrelor loading timing within the primary PCI workflow and ST-segment resolution in STEMI: a single-center real-world cohort study

We examined whether the timing of ticagrelor loading relative to culprit-lesion wire crossing within the primary PCI workflow was associated with ST-segment resolution (STR) after STEMI. The loading-to-wire-crossing interval was treated as a workflow-related timing measure rather...

TLR3 Overexpression Attenuates D-GalN/LPS-Induced Acute Liver Injury and Is Associated With AMPK Phosphorylation, Autophagy-Related Changes, and IRF3 Upregulation

Background: Toll-like receptor 3 (TLR3) has been implicated in innate immune regulation, but its role in acute liver injury is unknown. The aim of this study was to investigate the functional significance of TLR3 and its underlying mechanisms in D-GalN/lipopolysaccharide (LPS)-in...

Efficacy and safety of five femtosecond laser platforms in cataract surgery: a network meta-analysis informing platform-specific clinical decision-making

Abstract Background To compare the efficacy and safety of five femtosecond laser platforms (FLPs) in femtosecond laser-assisted cataract surgery (FLACS) and guide clinical selection. Methods Systematic searches (PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov...

CXCR4-targeted PET/CT with Al18F-NOTA-Pentixather shows superior sensitivity to 18F-FDG in thyroid follicular lymphoma.

F-FDG in low-grade lymphomas and suggests that CXCR4-targeted PET/CT may offer a more accurate reflection of disease burden, with potential implications for staging and therapeutic management.

Retrograde Transaortic Percutaneous Retrieval of a Left-Ventricularly Embolized LAmbre Occluder Followed by Same-Session Redo Left Atrial Appendage Closure: A Case Report

Abstract Background Left atrial appendage closure (LAAC) is an established stroke-prevention strategy for selected patients with atrial fibrillation who are unsuitable for long-term oral anticoagulation. Device embolization is rare but potentially life-threatening, particularly w...

Recent Advances in Comprehending Endothelial Dysfunction and Diabetic Cardiomyopathy: From Molecular Mechanisms to Clinical Applications

Diabetic cardiomyopathy (DCM) is a cardiac condition characterized by various structural and functional abnormalities that are associated with diabetes mellitus. Its development involves multiple factors, among which endothelial dysfunction plays a significant role. To fully desc...