Chengde Medical University

Research Progress on Small-Molecule Inhibitors Targeting Salt-Induced Kinases

Abstract As prominent members of the AMPK family, salt-induced kinases (SIKs) play pivotal roles in regulating cellular metabolism, immune responses, and the tumor microenvironment. Aberrant SIK expression is closely linked to oncogenesis, metabolic disorders, and inflammatory di...

WF-MobileNet: A Lightweight Wavelet–Fusion Network for Classifying Defects in 3D Surface Morphology Images of Seamless Steel Pipes

Seamless steel pipes require reliable classification of outer-surface anomalies, yet class imbalance, scale variation, and visual overlap between defects and production interference complicate automated inspection. We propose WF-MobileNet for classifying two-dimensional RGB pseud...

Artificial intelligence-driven identification and mechanistic exploration of synergistic anti-aging compounds from Dengzhan Shengmai formulation

Aging is a complex biological process involving multiple dysregulated pathways, and synergistic compound combinations offer distinct therapeutic advantages through multi-target and multi-pathway interactions. Traditional Chinese Medicine (TCM) formulations are inherently synergis...

Integrated transcriptomic and metabolomic analysis reveals the amino acid biosynthesis diversity in black and white mulberry

Abstract Mulberry fruits are recognized as highly nutritious dietary foods, offering a wide range of essential nutrients, antioxidants, and bioactive compounds that contribute to overall health. The nutritional value of the mulberry fruit is mainly attributed by the type and cont...