Chemical Synthesis Lab

Engineering an ( R )‐Selective Transaminase for High‐Substrate‐Loading Asymmetric Amination of a Sterically Demanding N ‐Heterocyclic Ketone

ABSTRACT The biocatalytic asymmetric amination of bulky N ‐heterocyclic ketones is often limited by low enzyme activity and poor performance at high substrate loading. Herein, we developed an efficient ( R )‐selective transaminase for the synthesis of ( R )‐1‐Boc‐3‐aminopiperidin...

Shewanella oneidensis employs both β-lactam resistance and tolerance controlled by the PghKR system

ABSTRACT Antibiotic tolerance enables bacterial survival during antibiotic exposure and can promote the evolution of resistance, thereby threatening therapeutic efficacy. However, the molecular mechanisms underlying tolerance and its relationship with resistance remain incomplete...

Bismuth nanoparticles supported on a high-surface-area nitrogen-doped carbon framework for electrocatalytic CO2 reduction

Bismuth (Bi) based catalysts exhibit high selectivity toward formate in the electrocatalytic reduction of carbon dioxide (CO 2 RR) but are limited by poor intrinsic conductivity and inefficient electron transport. Although three-dimensional (3D) architectures can enhance active s...

Mental health link workers in neighbourhood care: a theoretical application of the creative health communication framework

Purpose This article explores the conceptual application of the Creative Health Communication Framework (CHCF) to mental health and wellbeing support within integrated neighbourhood models of care. It proposes the introduction of specialist Mental Health and/or Creative Health Li...

Single-Atom Switching for Constructing a Full-Spectrum Hypochlorite-Responsive Probe Library: Screening Candidates for Water Analysis

Abstract Residual hypochlorite/hypochlorous acid (ClO–/HClO) is widely used in disinfection, yet simple assays integrating visual readout with quantitative fluorescence analysis remain limited. Herein, we report a single-atom-switching strategy for constructing a six-member, full...

Active Learning‐Accelerated Discovery of Antifungal Polymers With Self‐Assembly Capacity for Tackling Invasive Fungal Diseases

ABSTRACT Invasive fungal diseases (IFD) are life‐threatening infections with limited clinical management. Antifungal peptide (AFP)‐mimicking polymers are promising candidates for tackling IFD. However, due to the structural diversity of polymers, it remains a great challenge to d...

Metal‐Organic Framework‐Enabled Protection of Plasma DNA for Long‐Term Storage and Rare Mutation Detection

ABSTRACT Plasma DNA analysis remains a pivotal noninvasive approach for cancer diagnosis; however, the low abundance and rapid degradation of circulating tumor DNA (ctDNA) present significant challenges for sample preservation and transport. Existing stabilization methods often f...