Chelsea and Westminster Hospital

Growth trajectory and miscarriage diagnosis threshold in early IVF pregnancy: multicenter study

ABSTRACT Objectives To characterize early‐pregnancy ultrasound findings in pregnancies conceived via in‐vitro fertilization (IVF) for which gestational age is known precisely based on the date of embryo transfer (ET), and to examine their association with first‐trimester pregnanc...

Impact and sustainability of master trainer-led obstetric emergency skills training in Uganda: a qualitative study

BACKGROUND: Maternal mortality remains a major challenge in Uganda, where the maternal mortality ratio is 189 per 100,000 births - fifty time higher than in the UK. The Royal College of Obstetricians and Gynaecologists' Excellence in Obstetric Skills (EOS) and Resilience in Obste...

Exploring the relationship between gut microbiota and pan-cancer: a meta-analysis of Mendelian randomization studies

The relationship between the gut microbiota and cancer is of increasing interest, but remains incompletely understood. This study synthesized evidence from Mendelian randomization (MR) studies to assess the association between genetically predicted gut microbiota abundance and pa...

Total intravenous versus volatile anesthesia in living donor hepatectomy: A global prospective cohort study from the international LDLT registry

The choice between total intravenous anesthesia (TIVA) and volatile anesthesia for living donor hepatectomy remains controversial, with limited evidence comparing their impact on donor and recipient outcomes. This study evaluates the association between anesthetic technique and e...

HIV and anticholinergic burden: Towards a pragmatic stewardship algorithm

Abstract Background Multimorbidity and polypharmacy increase exposure to medications with anticholinergic properties in people with HIV. In elderly people, higher anticholinergic burden (ACB) is linked to cognitive impairment, falls, functional decline and mortality, whose risk i...

Bile acids and ursodeoxycholic acid alter gene expression in primary myometrial cells

Abstract Intrahepatic cholestasis of pregnancy (ICP), characterised by elevated maternal serum bile acids (BAs), increases risk of preterm labour that may be mitigated by ursodeoxycholic acid (UDCA) treatment. How different BA species, including UDCA, affect myometrial function r...

In-depth characterisation of the tumour microenvironment reveals HHV-8-dependent immune regulation in HIV-associated and classic Kaposi sarcoma

BACKGROUND: Kaposi's sarcoma (KS) is the most common malignancy occurring in people living with HIV (PLWH). The clinical course of KS in PLWH established on combined anti-retroviral therapy (cART) resembles that of classic KS. OBJECTIVES: To compare the clinical and biological ch...