Charlottesville Medical Research

The Ripple Effects of Misattributed Parentage: The Systemic Family Impact of “Not Parent Expected” Discoveries

ABSTRACT Direct‐to‐consumer (DTC) DNA testing has led to a surge in misattributed parentage discoveries, often referred to as “not parent expected” (NPE) events. While prior research has focused primarily on the experiences of those discovering a parent was not as expected, this...

Exposure to airborne fine particulate matter disrupts human embryonic stem cell osteogenic differentiation

Developmental bone toxicity encompasses impairments in skeletal growth and remodeling during embryonic and fetal development that can result in long-term skeletal abnormalities. Airborne fine particulate matter (FPM; ≤ 2.5 μm) is a size-defined fraction of particulate air polluti...

Label-free optical biomarker for prostate cancer diagnosis

Reprogramming of cellular metabolism in cancer leads to changes in the activity of metabolic coenzymes NAD(P)H and FAD which can be used as markers of tumorigenesis and metastasis. NAD(P)H and FAD form coupled redox pair and regulator of mitochondrial energy metabolism. Since NAD...