Charles River Laboratories (United States)

Scientific perspectives on in vivo developmental neurotoxicity testing: study design, regulatory context, and future directions

Developmental neurotoxicity (DNT) potential of (agro)chemicals is assessed in rodents according to OECD Test Guidelines (TG) 426 (DNT) or 443 (Extended One-Generation Reproductive Toxicity; EOGRTS) incorporating a DNT cohort. While the EOGRTS evaluates reproductive and neurotoxic...

Key challenges for in vitro testing of oral tobacco and nicotine products for regulatory applications: Recommendations for using in vitro toxicity and disease models

The Institute for In Vitro Sciences (IIVS) has sponsored a series of workshops with the aim of developing recommendations for scientific and technical approaches to conducting in vitro assays to assess potential toxicity within and across tobacco and nicotine products. As well as...