Charles R. Drew University of Medicine and Science

Gaps in diabetes care among people living with HIV and hypertension in Botswana: A cross‐sectional analysis of the InterCARE study

Abstract Objectives Data on diabetes screening and monitoring, within HIV care programmes in sub‐Saharan Africa, remain limited. This study describes the quality of diabetes screening and management among people living with HIV with comorbid hypertension receiving care at facilit...

Whole-genome 5-hydroxymethylation profiling of human neurons for regulatory and biological insight

Abstract While 5-methylcytosine (5mC) DNA methylation is a well-known player in genome stability and transcriptional regulation, the role of 5-hydroxymethylcytosine (5hmC), particularly prevalent in neurons, remains largely unknown. Here, we used long-read Oxford Nanopore Technol...

Perceptions of Safety and Fear of Seeking Emergency Care After 2025 Anti-Immigrant Policies

This cross-sectional study examines safety concerns and fear of seeking emergency care among English- and Spanish-speaking Latino patients following implementation of immigration policy changes in 2025.

From Ionic Agitation to Precision Neuroablation: A Bioengineering Perspective on the Mechanisms, Modalities, and Clinical Applications of Radiofrequency Technology in Pain Management

Radiofrequency ablation (RFA) is a foundational interventional technology in pain management. Despite the diversity of available systems, conventional thermal, internally cooled, bipolar, and pulsed radiofrequency (PRF) all share one biophysical mechanism: high-frequency alternat...

Perspectives on adverse events reporting in hybrid implementation science (IS) clinical trials of approved medications in Sub-Saharan Africa

Implementation science (IS) hybrid type 2 and 3 clinical trials and pure implementation research of approved medications test strategies to increase uptake of evidence-based interventions (EBIs) with well-established safety profiles. Guidance on adverse event (AE) monitoring and...

Enhancement of Anti-Neoplastic Effects of MGN-3/Biobran Against Solid Ehrlich Carcinoma-Bearing Mice via Lipidic Nanoparticle Based Targeted Drug Delivery System

MGN-3 (Biobran), a denatured hemicellulose compound derived from rice bran, possesses potent immunomodulatory and antitumor activity; however, its clinical application is constrained by non-specific tissue distribution, rapid systemic elimination, and poor cellular uptake. To ove...

Needs assessment of medical curricula development for patients with physical, intellectual, and/or developmental disabilities or non-english language preferences

Abstract Objective Individuals with physical, intellectual, and developmental disabilities (P/IDD) and those with non-English language preferences (NELP) experience significant health disparities, which have been traced to inadequacies in medical training. There is a need to crea...

Feasibility and acceptability of a compassion-focused program to support staff, improve workflows and enhance the clinic environment in South African primary health clinics with low ART retention

South Africa has the largest HIV epidemic globally. Despite improvement, retention on antiretroviral therapy (ART) remains challenging. We used a positive deviance (PD) approach to develop a program called Connect designed to increase retention in HIV care by improving the staff...

Decoding TnsC Filament Assembly in CRISPR-Associated Transposons Using Interpretable Deep Learning and Molecular Simulations

Abstract CRISPR-associated transposons (CASTs) enable programmable DNA integration, yet how the TnsC regulator forms processive filaments on DNA to coordinate RNA-guided transposition in type V-K CAST systems remains unknown. Here, we integrate large-scale molecular simulations,...

Ten years of student-reported outcomes from simulation-based interprofessional education in an underrepresented academic setting

Simulation-based interprofessional education is widely used to foster collaborative competencies among health professions students; however, evidence from underrepresented and minority-serving academic health settings remains limited. We conducted a retrospective program evaluati...