Changzhou University

Niacin Synthesis from 3-Cyanopyridine by Recombinant Escherichia coli: Optimization and Immobilization

Niacin (vitamin B3) is a high-value chemical widely used in the pharmaceutical and food industries. In this study, a recombinant Escherichia coli strain expressing nitrilase from Pseudomonas putida CGMCC3830 was evaluated for the whole-cell biotransformation of high-concentration...

Beyond CAR-T: Multi-layered engineering strategies shaping the next generation of cellular cancer immunotherapy

Adoptive cellular immunotherapy has transformed the treatment landscape for hematologic malignancies; however, its broader application to solid tumors remains limited by antigen heterogeneity, inadequate persistence, restricted tumor infiltration, and the profoundly immunosuppres...

Total Synthesis of Paliurine E by a Highly Convergent Block Approach

ABSTRACT Macrocycles occupy a privileged position in chemistry, biology and medicine, yet their broader exploitation is curtailed by the lack of general, efficient synthetic strategies. Current approaches to macrocycle construction rely largely on stepwise linear assembly, protec...

Elastic modulus recovery in concrete incorporating biomimetically mineralized recycled aggregates

Abstract The structural application of recycled aggregate concrete (RAC) is severely hindered by its low elastic modulus, primarily caused by porous adhered mortar and defective interfacial transition zone (ITZ). This study proposes a novel biomimetic mineralization strategy to c...

Electronic Nose‐Based Methanol Feedback Precision Control Strategy for High‐Yield Alkaline Phosphatase Fermentation by Hansenula polymorpha

ABSTRACT Alkaline phosphatase (ALP), an important industrial enzyme, has a wide range of applications in animal food, biotechnology, and environment. Methanol, as a key inducer in the fermentation process of Hansenula polymorpha , significantly affects ALP expression. This study...

Redox-Active Ligand-AssistedRuthenium-Catalyzed Lemieux–Johnson-TypeOxidation of Olefins for Aldehyde Synthesis

Abstract This work presents a ruthenium complex catalyst bearing redox-active ligands for highly selective oxidative cleavage of alkenes. The ligand serves as a dynamic electron reservoir with two core functions. Reversible electron transfer between the ligand and the Ru center g...

The EnantioselectiveRing-Opening of Six-MemberedCyclic Iodonium Salts for the Synthesis of Axially Chiral Diaryl EthersContaining Phosphinate Moiety

Abstract Construction of chiral compounds via the enantioselective ring opening of cyclic diaryliodonium salts represents a hot research topic in modern organic synthesis. In this work, an enantioselective ring-opening reaction of oxygen-fused six-membered cyclic diaryliodonium s...

Effectively Controllingthe Dispersion of FluorescentAgents in Polyethylene (PE) Matrix to Obtain Thermally Stable FluorescentComposite Fabrics

Abstract Fluorescent materials, as the core of flexible sensing, safety warning, and intelligent wearable fabrics, have attracted much attention for their synergistic improvement in functionality and stability. In response to the issues of inferior compatibility between fluoresce...