Changzhou Third People's Hospital

Morphologic and hemodynamic risk factors for paraophthalmic segment aneurysm rupture

To evaluate the impact of morphologic and hemodynamic characteristics on paraophthalmic segment aneurysms (PSAs) with the goal of identifying reliable risk factors for PSAs rupture. A case-control study was conducted among patients with a newly diagnosed PSAs who were treated at...

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

ABSTRACT Elevated copper levels are associated with chronic obstructive pulmonary disease (COPD) and susceptibility to acute exacerbations of COPD (AECOPD), but the underlying mechanisms remain unclear. This study aimed to investigate the association between copper levels and AEC...

Fulminant bleb-associated endophthalmitis caused by Streptococcus dysgalactiae successfully managed with endoscope-assisted vitrectomy: a case report

Abstract Purpose To describe a rare case of bleb-associated endophthalmitis caused by Streptococcus dysgalactiae and its successful management using endoscope-assisted vitrectomy combined with bleb repair. Case presentation A patient presented with light perception vision and ele...

Chinese herbal medicine (Yiqi Huayu Jiedu Decoction) combined with chemotherapy for preventing postoperative recurrence and metastasis in elderly gastric cancer patients: protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Abstract Introduction Gastric cancer (GC) has a generally unfavorable prognosis. Elderly patients often tolerate dual-drug chemotherapy poorly, experience limited benefits from monotherapy, and face high rates of postoperative recurrence and metastasis. To address this unmet clin...

Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework

Multimodal models capable of imputing diverse data used in single-cell biology studies provide potential foundational opportunities in clinical practice. However, patient data uniquely comprise longitudinal mosaic measurements that reflect underlying physiological dynamics and ex...

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

ABSTRACT Immune surveillance hinges on the precise regulation of molecular sentinels to maintain the equilibrium between physiological homeostasis and pathological distress. Central to this process is the sensing of exogenous pathogen‐associated molecular patterns (PAMPs) and end...

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Abstract Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, i...