Changzhou No.2 People's Hospital

Integrative genomic and functional analysis identifies BCL10 as a novel driver of trophoblast senescence in preeclampsia

OBJECTIVE: To identify senescence-driving genes causally linked to preeclampsia (PE) and to elucidate impact on placental dysfunction. METHODS: Placental RNA-seq data set GSE234729 was analyzed for differentially expressed genes. Weighted gene co-expression network analysis was u...

Molecular subclassification of MGMT-unmethylated high-grade glioma identifies divergent tumor states and therapeutic vulnerabilities

MGMT-unmethylated high-grade glioma (HGG) is associated with poor response to temozolomide and limited therapeutic options. However, substantial molecular heterogeneity exists within this clinically defined subgroup and remains insufficiently characterized. Transcriptomic and cli...

A novel ATP7A splice‑site variant with suspected maternal gonadal mosaicism in Menkes disease: functional validation and prenatal diagnosis

Abstract Menkes disease (MIM#309400) is a rare, fatal X-linked neurodegenerative disorder caused by ATP7A mutations. Delayed diagnosis due to clinical heterogeneity and limited data on mutational spectrum and reproductive risk remain challenges, with gonadal mosaicism being an of...

Morphologic and hemodynamic risk factors for paraophthalmic segment aneurysm rupture

To evaluate the impact of morphologic and hemodynamic characteristics on paraophthalmic segment aneurysms (PSAs) with the goal of identifying reliable risk factors for PSAs rupture. A case-control study was conducted among patients with a newly diagnosed PSAs who were treated at...

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

ABSTRACT Elevated copper levels are associated with chronic obstructive pulmonary disease (COPD) and susceptibility to acute exacerbations of COPD (AECOPD), but the underlying mechanisms remain unclear. This study aimed to investigate the association between copper levels and AEC...

Ultrasound‐Responsive Extracellular Vesicle‐Encapsulated Piezoelectric Nanoparticles for Chronic Inflammatory Pain Suppression

ABSTRACT Chronic inflammatory pain is characterized by the long‐term coexistence of central sensitization and neuroinflammation. Electrical stimulation has been demonstrated to be an effective strategy for alleviating chronic inflammatory pain. However, implanted electrodes have...

Association between perioperative changes in complement levels and postoperative delirium in elderly patients undergoing hip or knee arthroplasty: a prospective cohort study

Postoperative delirium (POD) is a common postoperative complication in elderly patients undergoing major surgery, characterized by an acute disturbance of consciousness and cognition occurring within a short period after surgery. POD has substantial adverse effects on patient hea...

Fulminant bleb-associated endophthalmitis caused by Streptococcus dysgalactiae successfully managed with endoscope-assisted vitrectomy: a case report

Abstract Purpose To describe a rare case of bleb-associated endophthalmitis caused by Streptococcus dysgalactiae and its successful management using endoscope-assisted vitrectomy combined with bleb repair. Case presentation A patient presented with light perception vision and ele...

MSTO1 promotes hepatocellular carcinoma progression and represents a potential target for immunotherapy

The incidence of hepatocellular carcinoma (HCC) has increased over recent decades. While significant progress has been achieved in immunotherapy, the five-year survival rate is still unsatisfactory because of the low response rate and acquired resistance in a few patients, which...

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis

Abstract Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that plays critical regulatory roles in multiple signaling pathways by preventing the ubiquitin-mediated degradation of its substrates. Dysregulated expression of USP7 is implicated in tumor progression; however, i...