Changzhi Medical College

Chemical Stabilization and Retention-Predictive Modeling for Regiospecific Profiling of Labile Monoacylglycerols by UHPLC–HRMS

Abstract Regiospecific analysis of monoacylglycerols (MAGs) remains challenging because of their low endogenous abundance, the limited availability of regioisomeric standards, and rapid acyl migration between the sn-1 and sn-2 positions during sample handling. Here, we report an...

Suppression of PKM2 by Leonurine Attenuates Alcoholic Hepatitis Through Regulating Glycolytic Reprogramming

Alcoholic hepatitis (AH) is a liver disease caused by long-term heavy drinking. In the early stages, it usually manifests as fatty liver, which can then develop into liver fibrosis and cirrhosis. Kupffer cells are liver resident macrophages and the effect of glycolytic reprogramm...

Fe-Coordinated Dopamine Derivative-Based Flame Retardant Epoxy Resin: Thermal Stability, Flame Retardancy, and Mechanism

Abstract With the increasing fire safety requirements of epoxy resin (EP), developing sustainable and efficient flame retardants has become highly desirable. In this work, a bio-based phosphorus–nitrogen flame retardant (DA-HCCP) was synthesized using dopamine (DA) and hexachloro...

Astragaloside IV improves MASLD via GCN5-LXRα/SREBP1c signaling pathway-mediated hepatic de novo lipogenesis

BACKGROUND: Astragaloside IV (AS-IV), a bioactive saponin from Astragalus membranaceus, shows promise for treating metabolic dysfunction-associated steatotic liver disease (MASLD), though its mechanisms remain unclear. PURPOSE: This study aimed to elucidate how AS-IV alleviates h...

Effect of thoracic paravertebral block with liposomal bupivacaine on quality of recovery after video-assisted thoracic surgery: a randomized controlled trial

Abstract Background The effect of thoracic paravertebral block with liposomal bupivacaine on recovery after video-assisted thoracic surgery remains uncertain. Methods This single-centre, double-blind, randomized controlled trial enrolled ninety adults aged 18 to 65 years who were...

Diagnostic challenges in primary aldosteronism evaluation and finerenone use

Primary aldosteronism (PA) is a common but frequently ignored cause of hypertension, particularly in patients with normal serum potassium and aldosterone levels. We report the case of a 70-year-old Han Chinese man with a 20-year history of hypertension who presented with normokal...

Association between sarcopenia and hypertension: results from large databases in China and the United States

Sarcopenia and hypertension are prevalent conditions with substantial public health implications. However, whether their association is consistent across different populations remains unclear. This study aimed to investigate the association between sarcopenia and hypertension usi...

Gypenosides Damulin A and Damulin B Inhibit Hepatocellular Carcinoma by Regulating Cholesterol Synthesis

Hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive system. The liver is the primary organ for cholesterol production and metabolism in the body. Abnormal cholesterol levels can promote the initiation and progression of liver cancer, as well as influence t...

Electrochemical Nickel-Catalyzed Cross-Electrophile Coupling: A Sustainable Platform for C(sp3)–C(sp3)/C(sp2) Bond Construction

Abstract An electrochemical nickel-catalyzed cross-electrophile coupling reaction of organic halides with cyclosulfonium salts to construct C(sp3)–C(sp3)/C(sp2) bonds is reported. This highly selective synthetic approach demonstrates significant practical utility, as evidenced by...

Determinants of a positive resection margin (R1 status) in esophageal squamous cell carcinoma: a retrospective analysis of 148,121 cases from China

To investigate risk factors for positive proximal and distal resection margins after surgery for esophageal squamous cell carcinoma (ESCC). Total initially enrolled esophageal squamous cell carcinoma patients were 148,121 cases. After strict case screening and quality control, a...

Crystal structure of N -(2-(phenylethynyl)phenyl)methanesulfonamide

Abstract C 15 H 13 NO 2 S, monoclinic, P 2 1 / n (no. 14), a = 11.2461(1) Å, b = 5.6180(1) Å, c = 20.4958(2) Å, β = 91.642(1)°, V = 1294.41(3) Å 3 , Z = 4, R gt ( F ) = 0.0340, w R ref ( F 2 ) = 0.0877, T = 100 K.

SPR‐UPLC‐QTOF/MS‐GNPS‐Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor‐Binding Small‐Molecule Lead for Inflammatory Storm Intervention

ABSTRACT This study developed an integrated strategy combining surface plasmon resonance (SPR) for real‐time biomolecular interaction analysis, ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry (UPLC‐QTOF/MS) for compound profiling,...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...