Changshu No.1 People's Hospital

PITRM1-AS1 attenuates the ferroptosis of gastric cancer via TAF1-mediated KDM3B transcription

This study aimed to identify ferroptosis-related lncRNAs in gastric cancer (GC), with a view to providing novel insights into GC therapy by inducing ferroptosis. Bioinformatics analysis was conducted to screen ferroptosis-related lncRNAs and further identified their expression at...

Prediction of Claudin18.2 expression in gastric adenocarcinoma by habitat radiomics based on spectral CT

To explore the predictive value of habitat radiomics derived from Dual-layer spectral detector CT (DLSCT) for the preoperative evaluation of Claudin18.2 (CLDN18.2) expression in gastric adenocarcinoma. A retrospective cohort of 111 eligible patients with gastric adenocarcinoma wh...

Knowledge, attitudes, and practices of patients and family members regarding the use of susceptibility-weighted imaging-based optimized substantia nigra imaging in Parkinson’s diagnosis

This study evaluated the knowledge, attitudes, and practices (KAP) regarding susceptibility-weighted imaging-based optimized substantia nigra (SN-SWI) among patients with Parkinson’s disease (PD) and family members in Suzhou, China. A cross-sectional survey was conducted between...

The relationship between serum E2F1 and MMP-9 levels and clinical and pathological characteristics and prognosis in patients with epithelial ovarian cancer

To investigate the association between serum levels of E2F transcription factor 1 (E2F1) and matrix metalloproteinase 9 (MMP-9) in patients with epithelial ovarian cancer (EOC) and their clinical and pathological characteristics and prognosis, with the aim of identifying potentia...

Gut microbiota-derived indoleacrylic acid ameliorates rheumatoid arthritis by preventing necroptosis of fibroblast-like synoviocytes and regulating macrophage polarization

Rheumatoid arthritis (RA) is associated with gut metabolite dysfunction, but the contribution of tryptophan-derived metabolites to RA remains fully uncharacterized. Here, we investigated the role of the gut microbiota-derived tryptophan metabolite indoleacrylic acid (IA) in exper...