Changsha Central Hospital

Young bone marrow mesenchymal stem cell-derived exosomes promote perfusion recovery and tissue repair via the miR-455-5p/Bach1 axis after hindlimb ischemia

Lower-limb ischemia caused by peripheral arterial disease (PAD) results in sustained perfusion impairment and tissue injury, and effective regenerative therapies remain limited. Bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos) are a promising cell-free therapeutic s...

Dissecting the associations of cardiovascular health, biological aging, and blood DNA methylation signatures with chronic respiratory disease risk

The interplay between cardiovascular health (CVH), biological aging, and underlying epigenetic mechanisms in relation to chronic respiratory diseases (CRDs) remains unclear. We conducted a large-scale prospective cohort study including 181,955 participants from the UK Biobank. Ca...

The association between Oxidative Balance Score and anemia in adults

Oxidative stress is implicated in the pathogenesis of anemia. The Oxidative Balance Score (OBS), a comprehensive metric assessing the combined impact of dietary and lifestyle factors on oxidative stress, has not yet been investigated in relation to anemia prevalence. We conducted...

miR‐7641: A Novel Diagnostic Biomarker for Rheumatoid Arthritis That Exerts Protective Effects by Targeting TNFSF10

ABSTRACT Rheumatoid arthritis (RA) is closely associated with genetic factors, but there is still a lack of ideal biomarkers for its early diagnosis and precise intervention. To investigate the diagnostic value and synovial cell function of miR‐7641 in RA, and its mechanistic lin...

Accuracy assessment of Chinese large language models in psoriasis management: a multicenter expert evaluation study

Psoriasis patients in China face severe barriers to disease knowledge acquisition and limited access to medical resources, creating an urgent demand for reliable, evidence-based patient education tools. This multicenter expert evaluation study aimed to systematically assess the q...

Spectral-habitat analysis and perfusion fingerprinting on contrast-enhanced ultrasound for characterizing tumor perfusion in breast lesions

To develop a short-time Fourier transform (STFT)-based perfusion fingerprinting method combined with spectral-habitat analysis for characterizing pixel-wise perfusion heterogeneity on contrast-enhanced ultrasound (CEUS) and to evaluate its ability to differentiate benign and mali...

Dynamic serum IgM monitoring may refine response assessment in IgM-secreting marginal zone lymphoma: a two-center retrospective exploratory case series

We retrospectively evaluated whether dynamic serum IgM monitoring could complement PET/CT-based response assessment in 53 patients with IgM-secreting marginal zone lymphoma from two centers. A total of 112 paired IgM and PET/CT assessments were analyzed. Repeated-measures correla...

Stress Hyperglycemia Drives CD4 + T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

ABSTRACT Perioperative stress hyperglycemia is a transient but frequent metabolic disturbance strongly linked to postoperative organ injury and mortality; however, the immunometabolic mechanisms driving this association remain largely undefined. In a two‐center cohort of patients...