Institution
Changping Laboratory
Recent research
- BiologyOpen access
Abstract Trophoblast lineages are essential for placental development and play indispensable roles in mammalian development. However, the regulatory mechanisms governing trophoblast lineage specification, particularly trophectoderm formation, remain elusive. Here, we show that tr...
- Health & Medicine
The continuous antigenic evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly undermined the effectiveness of monoclonal antibody (mAb) therapies, underscoring the need for innovative approaches that improve therapeutic mAb breadth and durabili...
- Biology
Abstract Machine-learning-guided directed evolution can reduce the experimental burden of protein engineering by prioritizing variants before they are tested. In practice, however, many campaigns begin with few or no target-specific measurements, face choices about how to use het...
- BiologyOpen access
Methyl-donor inhibitors relax 3D genome structures to promote totipotent reprogramming
The 3D genome safeguards cell identity while shaping developmental plasticity, yet its coordination with metabolism during cell fate transitions remains unclear. Here, we use a mouse totipotent stem cell induction system to dissect the role of methyl-donor metabolism in 3D genome...
- Biology
LAMP: Large-Area Molecular Mapping Platform
Abstract By providing unique chemical specificity and quantitative metabolic imaging, label-free stimulated Raman scattering (SRS) and coherent anti-Stokes Raman scattering (CARS) microscopy is now emerging as the next-generation clinical decision maker by providing molecular con...