Changhua Christian Hospital

Red cell distribution width-to-albumin ratio at discharge predicts 14-day hospital readmission in nephrology inpatients: a retrospective cohort study

Hospital readmission within 14 days of discharge carries clinical and economic costs, particularly in nephrology patients whose inflammatory and nutritional status influence early recovery. The red cell distribution width-to-albumin ratio (RAR) is an inexpensive index that captur...

High‐Resolution IVIM MRI Characterizes Diffusion–Perfusion Properties of the Parasagittal Dura

The objectives of this study were to characterize the diffusion-perfusion properties of the parasagittal dura (PSD) using high-resolution intravoxel incoherent motion (IVIM) MRI and to explore whether PSD-specific IVIM metrics reflect distinct fluid-transport-related signal behav...

Fucoidan from Fucus Vesiculosus Alleviates Interstitial Cystitis by Suppressing the AKT/NLRP3 Inflammasome Axis

Background/Objectives: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory bladder disorder that lacks an effective treatment agent. Fucoidan (FUC), isolated from Fucus vesiculosus, is a sulfated polysaccharide that exhibits potent anti-inflammatory and...

Selectivity Filter KCND3 Variant Causes Spinocerebellar Ataxia 19/22 and K V 4 .3 Functional Loss

Abstract Background Spinocerebellar ataxia type 19/22 (SCA19/22) is a rare autosomal dominant neurodegenerative disorder caused by KCND3 variants encoding the K V 4.3 potassium channel. While most pathogenic variants result in loss‐of‐function (LOF), no pathogenic variants were p...

Risk stratification of lung malignancy in a real-world LDCT cohort: implications for screening beyond smoking criteria in Taiwan

Low-dose computed tomography (LDCT) screening has been widely implemented based primarily on smoking-related eligibility criteria derived from Western populations. However, lung cancer epidemiology differs substantially in Asia, where a considerable proportion of cases occur amon...

Beyond Caregiving: Recovery and Growth Among Primary Caregivers Following the Loss of a Family Member Living With Dementia

BACKGROUND: Caring for a family member with dementia places long-term emotional, physical, and social strain on primary caregivers. Although extensive research has examined the caregiving phase, relatively few studies have explored caregivers' recovery experiences following berea...

Association Between Bladder Management Strategies and Symptomatic Urinary Tract Infections in Patients with Chronic Spinal Cord Injury: Lessons from a 5-Year Longitudinal Cohort

Background: Urinary tract infections (UTIs) are a leading cause of morbidity in patients with chronic spinal cord injury (SCI). This study examined the incidence of first and recurrent symptomatic UTIs in patients with chronic SCI and explored clinical factors associated with inf...

The double-decking method for rezūm water vapor therapy in benign prostatic hyperplasia: volumetric, functional, and dosimetric outcomes

Abstract Background Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) significantly impact quality of life in aging men. Conventional Rezūm water vapor therapy consistently achieves only a modest 25–30% prostate volume reduction, leaving a clinic...

The association between depression and frozen shoulder: A systematic review and meta-analysis

BackgroundFrozen shoulder (FS), commonly known as adhesive capsulitis, is a disabling musculoskeletal condition frequently accompanied by psychological distress. This meta-analysis aimed to evaluate the association between FS and depression.MethodsFor this meta-analysis, a system...

Prevalence of dementia and BPSD in community-dwelling older adults with advanced care needs: a nationwide survey in Taiwan

Background Caring for people with both dementia and advanced care needs is complex. This study aimed to elucidate the prevalence of dementia and behavioral and psychological symptoms of dementia (BPSD) in patients receiving advanced care, including tube feeding, respiratory care,...

Glycemic and Lipid Outcomes Associated with Bitter Melon Blood-Sugar-Modulating Protein and Metformin Use: A Translational Preclinical and Retrospective Study

Background/Objectives: Interactions between botanical supplements and standard antidiabetic therapies remain poorly understood. This study investigated the efficacy and mechanistic properties of a bitter melon blood-sugar-modulating protein (BMP) in relation to concurrent metform...