Changchun University of Chinese Medicine

Individualized multimodal pain management for chronic perineal pain

Rationale: Persistent perineal pain is a challenging clinical condition that may substantially impair sleep, urination, daily activities, and psychological well-being. Accurate assessment and individualized multimodal management are essential for improving symptom control and pat...

Fenvalerate Induces Airway Epithelial Injury Through CHRM3-Associated NF-κB Activation

Fenvalerate (FEN) is a widely used pyrethroid insecticide with potential respiratory toxicity; however, its contribution to chronic obstructive pulmonary disease (COPD)-related pathological processes remains unclear. We investigated molecular mechanisms linking FEN exposure to ai...

Interpretable machine learning for identifying mild cognitive impairment among Chinese patients with obstructive sleep apnea: a multicenter cross-sectional study

Mild cognitive impairment (MCI) is clinically relevant in obstructive sleep apnea (OSA). We developed and externally validated an interpretable machine-learning model for concurrent clinically defined MCI to support prioritization for formal cognitive assessment rather than diagn...

Modulation of Arachidonic Acid Metabolism by Pinoresinol Diglucoside Ameliorates Osteogenic Dysfunction via Coordinated NF ‐ κB Suppression and GSK3β /β‐Catenin Activation in Diabetic Osteoporosis

ABSTRACT Diabetic osteoporosis (DOP) is characterized by chronic low‐grade inflammation and impaired bone formation. Pinoresinol diglucoside (PDG), a bioactive compound derived from Eucommia ulmoides Oliv., has shown therapeutic potential in metabolic bone disorders; however, its...

The effect of cognitive behavioral therapy for sleep and glycemic outcomes in people with diabetes

Background: Sleep disturbances are highly prevalent in individuals with diabetes and are associated with various adverse physiological, psychological, and social consequences. A growing body of research supports the effectiveness of cognitive behavioral therapy (CBT) in managing...

Effects of approved anti-obesity medications on depression symptoms, psychiatric adverse events, and quality of life in adults who are overweight or obesity: a systematic review and Bayesian network meta-analysis

Pharmacological weight management has expanded rapidly with the introduction of GLP-1 receptor agonists and dual GIP/GLP-1 agonists, yet their comparative effects on mental health remain unclear. We systematically searched PubMed, Embase, Cochrane CENTRAL, PsycINFO, and ClinicalT...

Engineering of Azo-Crosslinked Alginate Hydrogels for Targeted Oral Local Biologic Delivery

Abstract Oral delivery of therapeutic biologics is constrained by gastrointestinal degradation and premature leakage from physical hydrogels. Here, microfluidic-engineered azo-crosslinked alginate (SA-Azo) microspheres were fabricated via template-assisted covalent substitution,...

Machine Learning for Screening Bioactive Compounds in Traditional Chinese Medicine: Computational Prediction, Multi-Omics Integration, and Clinical Translation Potential

Identifying bioactive compounds in traditional Chinese medicine (TCM) requires computational prioritization to be connected with chemical and pharmacological evidence. This structured narrative and critical review examines machine learning applications in compound prediction, for...

Integrative analysis of chemical profiling proposes sesamin as a computationally prioritized, putatively annotated candidate in SQ–DS–HQ for diabetic neuropathy

Diabetic peripheral neuropathy (DPN) is a common diabetes complication with complex inflammatory, hypoxic and neurodegenerative features. Sanqi–Danshen–Huangqi (SQ–DS–HQ) is a traditional Chinese herbal formula used for diabetes-related complications, yet its chemical basis and m...

Comparative efficacy of Chinese patent medicines for pain, disability, and bone density in osteoporotic vertebral compression fractures after percutaneous vertebral augmentation: a network meta-analysis

Abstract Background Osteoporotic vertebral compression fractures (OVCFs) are common in elderly patients, and managing postoperative issues after percutaneous vertebral augmentation remains a significant challenge. Chinese patent medicines are considered beneficial complementary t...

Untargeted UHPLC–Q-Orbitrap-MS/MS profiling of six bamboo taxa for comparative chemical discrimination and SHAP-guided prioritization of antioxidant-associated metabolites

Bamboo leaves are phenolic-rich botanical materials with potential food and health applications, but their inter-taxon chemical heterogeneity complicates chemotaxonomic differentiation and chemistry-based quality evaluation. Here, untargeted ultra-high-performance liquid chromato...

In-Situ Synthesis of CuF2 Integrated Cathodes for High-Performance Lithium Metal Batteries with Superb Stability

Abstract Copper fluoride (CuF2) exhibits high theoretical specific capacity and an attractive redox potential, making it a promising lithium metal batteries (LMBs) cathode material. Nevertheless, its cycling performance remains inadequate, with severe capacity loss occurring over...

Endurance exercise and central fatigue

Background: Endurance exercise, characterized by sustained low-to-moderate intensity training, enhances physiological performance during prolonged physical activity and is widely used in sports training and the rehabilitation of chronic diseases. Central fatigue, a key issue in e...

Exploring the potential mechanism of Xiaoqinglong Decoction in the treatment of acute exacerbations of chronic obstructive pulmonary disease based on network pharmacology and in silico study

Xiaoqinglong Decoction (XQLD) is a traditional Chinese herbal formula widely used in clinical practice to treat acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with notable efficacy. Studies indicate that XQLD can effectively modulate the inflammatory respon...

Shared oral microbiome signatures linking periodontitis and autoimmune thyroiditis: NHANES 2009–2012

Objective To examine the association between periodontitis severity and autoimmune thyroiditis (AIT) in a nationally representative US sample and to explore oral microbiome features shared between the two conditions.Methods We analyzed adults from NHANES 2009–2012 with complete p...

Modulating the Thermodynamics and Kinetics of Psychedelics at Serotonin Receptors via Terahertz Waves

Abstract Precise control over the thermodynamics and kinetics of receptor–ligand interactions is pivotal for manipulating physiological processes and developing targeted therapies. However, conventional pharmacological approaches often lack the spatiotemporal precision required f...

Dynamic Supramolecular Helicity in a Multi-Aluminum Porphyrin Catalyst Enables Stereocontrolled Synthesis of Ultrahigh-Molecular-Weight Isotactic Poly(propylene oxide)

Abstract Isotactic poly(propylene oxide) (iPPO) is a robust polyether with photodegradability. However, its stereoselective synthesis from racemic propylene oxide (rac-PO) remains dominated by preconfigured axially chiral cobalt/chromium bimetallic catalysts. Here, we report an i...

Latent profiles and associated factors of self-management behaviours among middle-aged and older adults with type 2 diabetes

Type 2 diabetes requires sustained self-management across multiple behavioural domains, yet middle-aged and older adults may not follow a single high-versus-low pattern. This study aimed to identify latent profiles of self-management behaviours among middle-aged and older adults...

Early renal perfusion phenotypes and renal recovery in critically ill patients with or at risk for acute kidney injury: a prospective multicenter cohort study

BACKGROUND: Acute kidney injury (AKI) in critical illness is heterogeneous, and conventional Kidney Disease: Improving Global Outcomes (KDIGO) classification may not capture early physiologic differences relevant to renal recovery. METHODS: Critically ill adults with or at risk f...

Global Trends and Research Hotspots in Natural Products for Hyperuricemia: A Bibliometric Analysis (2004–2026)

Hyperuricemia (HUA) is a key pathological basis for gout and uric acid (UA) nephropathy, and its increasing global prevalence presents a substantial public health challenge. Natural products (NPs) have emerged as a research hotspot due to their potential to reduce UA and favourab...