Changchun Institute of Biological Products

Development of a cross-protective subunit cocktail vaccine against diverse serotypes of Glaesserella parasuis infection in pigs

Abstract Glässer’s disease, caused by Glaesserella parasuis (GPS), causes substantial economic losses in the swine industry worldwide. This situation is largely attributable to the poor cross-protective efficacy of currently available vaccines. In this study, a multi-antigen cock...

A Recombinant RABV-G-Based Chemiluminescence Immunoassay for Quantitative Detection of Rabies Virus Antibodies

Background: Rabies is a nearly 100% fatal zoonosis, and a rabies virus-neutralizing antibody (RVNA) titre of ≥0.5 IU/mL is the recognized correlate of protection, making post-vaccination serological monitoring essential. However, the gold-standard methods (RFFIT and FAVN) are tim...

Consensus H3N2 HA immunogens incorporating key antigenic mutations elicit broad-spectrum neutralising responses

Seasonal influenza A/H3N2 poses a significant public health burden due to its rapid antigenic evolution, necessitating frequent vaccine updates. This study systematically analysed the antigenic evolution of 14 H3N2 vaccine strains (2000-2022) using pseudovirus-based neutralisatio...

Preparation and Characterization of Core–Shell‐Structured Polyaniline Nanocomposites With Combined Electrical Conductivity, Magnetic Properties, and Fluorescence Performance

ABSTRACT A Ni 0.5 Zn 0.5 Fe 2 O 4/ SiW 11 Ni/PANI core–shell nanocomposite was prepared via one‐step inverse microemulsion polymerization, achieving integrated control of conductivity, soft magnetism, and blue photoluminescence. Spinel Ni–Zn ferrite (∼15 nm, 59.95 emu/g) was firs...

Guidelines for Studying Mutagenesis in Quiescent Schizosaccharomyces pombe

All living organisms can enter a non-dividing state known as quiescence, which often functions as a survival strategy. In many cases, quiescent cells retain the ability to re-enter the cell cycle when conditions become favorable. Therefore, preserving the integrity of non-dividin...