Chang Gung Memorial Hospital

Targeting AHNAK ameliorates osteonecrosis of the femoral head and affects adipogenic pathways involving Smad/PPARγ

Aims This study aimed to investigate the role of AHNAK in patients with osteonecrosis of the femoral head (ONFH) and its association with bone adipogenesis. Non-traumatic ONFH, primarily driven by steroid use and alcohol consumption, results in an imbalance between osteogenesis a...

Optimizing Field-of-View for Type-1 Retinopathy of Prematurity via Multiple Instance Learning

Purpose: The purpose of this study was to cut down on screening time and costs, this study optimizes field-of-view (FOV) combinations for classifying type-1 retinopathy of prematurity (ROP) through multiple-instance learning (MIL) that models clinical decision making. Methods: Th...

Development ofa Shapley Additive Explanations (SHAP)-InterpretableModel for Cardiovascular Risk Stratification in Type 2 Diabetes Mellitus:Implications of MDA-Modified Protein Adducts and Autoantibodies

Abstract Coronary artery disease (CAD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM). This study explores the two-hit oxidative–immune hypothesis by evaluating malondialdehyde (MDA)-modified protein (MDA-protein) adducts and their corresponding autoantibodi...

Smyca-FOXM1 ribonucleoprotein complex promotes homologous recombination and tumor immune evasion to define a therapeutic target of triple-negative breast cancer

BACKGROUND: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited treatment options. Although PARP inhibitor (PARPi) offers great promise in treating TNBC with deficiency in homologous recombination (HR), most TNBC patients are HR-profi...

Same-day EHR-coded sevoflurane versus propofol exposure and long-term coded dementia in older surgical adults: a propensity-matched cohort study

Whether perioperative EHR records of sevoflurane and propofol identify clinically meaningful differences in long-term dementia risk is uncertain. We compared same-day EHR-coded sevoflurane versus propofol exposure in relation to subsequent coded dementia among older adults underg...

Prognostic Accuracy of the Phoenix Sepsis Criteria for Mortality in Children With Suspected Infection: A Systematic Review and Meta-Analysis

Objectives: We aimed to evaluate the pooled prognostic accuracy of the Phoenix Sepsis Criteria (PSC) for in-hospital mortality and compare its performance with the International Pediatric Sepsis Consensus Conference (IPSCC) criteria in children with suspected infection. Data Sour...

Neurocognitive Functions and Their Associations With Autistic Symptoms, Emotion, and Behavior in High-Functioning Children and Adolescents With Autism Spectrum Disorder

Objective Studies have revealed the prognostic significance of intelligence in children with autism spectrum disorder (ASD), but the correlations of non-social cognitive functions and clinical characteristics of high-functioning children and adolescents with ASD remain unclear. T...

Fracture morphology guides the selection of closed versus open reduction in straddle fractures: outcomes of an indication-based treatment strategy

To identify fracture characteristics associated with the selection of closed reduction (CR) or open reduction (OR) for anterior pelvic ring fixation in patients with straddle fractures and to evaluate the radiographic, functional, and complication outcomes following an indication...