Chang Gung Memorial Hospital

Cross-cultural adaptation and validation of the Traditional Chinese NASA Task Load Index (NASA-TLX) for assessing perceived workload in Taiwanese adults

Background Perceived workload is central to occupational health, ergonomics, and rehabilitation research, yet no guideline-based Traditional Chinese version of the NASA Task Load Index (NASA-TLX) has been available for Taiwan and other Traditional-Chinese-speaking settings. Objec...

Reliability-aware dual-representation DCE-MRI segmentation with disagreement-guided quality control for breast tumor delineation

Automated breast tumor segmentation on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may support quantitative imaging analysis, but case-level segmentation failures remain a concern in heterogeneous multicenter data. We evaluated a reliability-aware dual-represen...

Clinical and radiological outcomes of reverse shoulder arthroplasty without preoperative 3D digital planning: a single-surgeon retrospective cohort study

This study aimed to evaluate whether reverse shoulder arthroplasty (RSA) can achieve reliable clinical and radiological outcomes when performed using standard instrumentation without preoperative 3-dimensional (3D) digital planning in patients with relatively normal anatomy. We c...

Clinical Implications of the Novel Genetic Polymorphism Associated With Retinal Vein Occlusion: The East Asian GWAS Survey in a Single-Center Taiwanese Cohort

Purpose: To explore the single-nucleotide polymorphic features in an East Asian cohort of retinal venous occlusion (RVO) patients, to map pathogenic genes, and to analyze potential pathophysiological associations. Methods: This was a cross-sectional monocentric cohort study invol...

Continuous infusion of granulocyte colony-stimulating factor is associated with an advantage in neutrophil recovery in pediatric oncologic disorders

INTRODUCTION: The use of intensified chemotherapy has significantly improved overall survival (OS) and relapse-free survival (RFS) in cancer patients. However, it also increases the risk of chemotherapy-induced neutropenia (CIN). Granulocyte colony-stimulating factor (G-CSF) is c...

Three-dimensional evaluation of dental adaptation and skeletal stability following posterior open-contact surgical occlusion

Abstract This study evaluated the effects of different surgical occlusion designs, particularly posterior open contacts, on dental movement, skeletal stability, and occlusal outcomes in orthognathic surgery. A total of 49 skeletal Class III patients were classified into tripod co...

Spatial transcriptomic analysis of progressing oral epithelial dysplasia reveals unique differentially expressed genes and microenvironmental changes.

Oral squamous cell carcinoma (OSCC) often arises from oral epithelial dysplasia (OED); however, the gene expression changes during OED progression and its microenvironment are not fully understood. This study used spatial transcriptomics to identify differentially expressed genes...

Targeting a miRNA–mRNA regulatory network to overcome radioresistance in head and neck cancer: identification of I-OMe-AG-538 via transcriptome-guided drug repurposing

Abstract Radioresistance is a major obstacle to successful radiotherapy in head and neck cancer (HNC), leading to treatment failure, recurrence, and poor patient outcomes. MicroRNAs (miRNAs) are key post-transcriptional regulators implicated in radiosensitivity, but comprehensive...

Lumikine Attenuates Ventilation-Induced Lung Injury in Mice with Lipopolysaccharide-Induced Lung Fibrosis

Lipopolysaccharide (LPS) induces pulmonary fibrosis by increasing microvascular permeability and inducing severe inflammation and extracellular matrix accumulation. Mechanical ventilation (MV), although life-sustaining, can increase inflammatory cytokine production, oxidative str...

Targeting the Gut Vascular Axis in Atherosclerosis: Probiotic and Phytoantioxidant Crosstalk as a Hypothesis-Generating Framework for Residual Cardiovascular Risk

Despite decades of effective statin therapy, a clinically important proportion of patients with atherosclerosis continue to experience ischemic events, even when low-density-lipoprotein cholesterol (LDL-C) is at guideline-recommended levels. This shortfall is increasingly attribu...

A bioactive cell sheet interface regulates scaffold–host interactions for cartilage regeneration

Abstract Cartilage tissue engineering remains challenged by uncontrolled scaffold–host interactions after implantation, particularly host tissue infiltration that can disrupt cartilage formation and compromise scaffold integrity. Although biomaterial‐based encapsulation strategie...

Endoscopic-assisted percutaneous reconstruction of chronic Achilles tendon ruptures with allograft Achilles tendon: a report of two cases with novel surgical technique

Chronic Achilles tendon ruptures with large defects are difficult to reconstruct because of tendon retraction, poor tissue quality, and the risk of wound complications associated with open surgery. This report describes a novel endoscopic-assisted percutaneous technique for Achil...

Eco-responsive CeCo-MOF/g-C3N4 heterointerfaces for electrochemical detection of nilutamide in aquatic systems

The widespread occurrence of pharmaceutical contaminants in aquatic environments necessitates the development of sensitive and sustainable sensing platforms for environmental monitoring. In this work, a bimetallic cerium‑cobalt metal-organic framework (CeCo-MOF) integrated with t...

Reoperations After Soft Tissue Release for Spastic Hip Displacement: Which One Matters More-Migration Percentage, Acetabular Index, or Motor Function?

INTRODUCTION: Current treatments for hip displacement in cerebral palsy primarily rely on the migration percentage (MP). The literature highlights various factors contributing to treatment failure, though the significance of each remains debated. This study aimed to identify pred...

Epstein-Barr virus reactivation and post-transplant lymphoproliferative disease risk deserve a place in the JAK inhibitor toxicity profile. Comment on: “Janus kinase inhibitors as an evolving treatment for lymphomas and immune-mediated complications”

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Campylobacter jejuni genotoxin promotes intestinal inflammation via the DNA damage-cGAS-STING signaling axis

The foodborne agent Campylobacter jejuni is a pervasive zoonotic pathogen and a major cause of gastrointestinal disease associated with inflammatory disorders in humans. While its genotoxin, cytolethal distending toxin (CDT), induces DNA damage, the toxicological signaling events...

Adverse pregnancy outcomes in women with atopic dermatitis: A systematic review and meta‐analysis

Abstract Background The impact of atopic dermatitis (AD) on pregnancy outcomes has been largely uncertain, and clarifying this association is essential for improving maternal counselling, risk stratification and clinical management. Objectives To assess the association between AD...

Machine learning-based prediction of intraoperative desaturation risk in pediatric dental sedation using preoperative data

Dental sedation in children is widely used to reduce anxiety and facilitate successful dental procedures. However, intraoperative desaturation remains a significant safety concern. This study aimed to evaluate whether machine learning models using only readily available preoperat...

Tinea capitis in children in Northern Taiwan: An update from 2020 to 2024

Abstract Background: Tinea capitis is the most common fungal infection in children. The prevalent pathogen differs by region and shifts over time. Objectives: To investigate the current epidemiological, clinical, and mycological characteristics of tinea capitis in children in nor...

The burden of suicide by paraquat poisoning in Taiwan (1987–2017): trends, geographic variations, and demographic characteristics

Pesticide self-poisoning accounts for 14%–20% of global suicides. Paraquat, a highly lethal pesticide, is involved in a considerable number of suicides in some countries. This study investigated the burden, trends, geographic variations, and demographic characteristics of pestici...