CHA University Bundang Medical Center

Prioritizing Emergency Medical Conditions for Health Policy Using a Stepwise Treatable-Death Framework: A Nationwide Analysis in Korea, 2018–2022

Background/Objectives: Limited emergency-care resources require priorities based not only on mortality rates or death counts but also on the potential mortality reduction under explicit targets. We applied the age- and sex-standardized domestic short- and mid-term components of a...

Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial

PURPOSE: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovasc...

Comparison of Neurophysiological Characteristics Using Heart Rate Variability Between Patients With Korean Hwa-byung and Healthy Individuals

Objective Hwa-byung (HB) is a syndrome associated with stressful events within Korea’s social and cultural contexts. The clinical symptoms of HB may be associated with autonomic imbalance. This study investigated the neurophysiological characteristics of HB by comparing heart rat...

Personalized deep learning for short-term forecasting of impending atrial fibrillation from continuous wearable ECG signals

Abstract Continuous wearable electrocardiogram (ECG) monitoring is increasingly used for ambulatory arrhythmia surveillance, yet forecasting impending atrial fibrillation (AF) remains challenging because of inter-patient ECG variability. We investigated whether personalizing a gl...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Risk of peripheral artery disease following ankylosing spondylitis, 2012–2023: a nationwide cohort study in South Korea

OBJECTIVE: Ankylosing spondylitis (AS) is a chronic inflammatory disease linked to systemic vascular complications. Evidence regarding the association between AS and peripheral artery disease (PAD) remains limited. We investigated whether patients with AS have an increased risk o...

Extracellular vesicles derived from the lactic acid bacterium Enterococcus rotai suppress melanogenesis by modulating the cAMP-MITF pathway

Enterococcus rotai CMTB-CA6-derived extracellular vesicles (CA6-ErEVs), isolated from a Centella asiatica -associated lactic acid bacterium, were investigated for their potential to modulate oxidative stress, inflammation, and melanogenesis in skin cells. CA6-ErEVs were purified...

Prognostic Role of Adverse Events in a Worldwide Population of Patients with Biliary Tract Cancer Treated with Chemo-Immunotherapy

Background: Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. The addition of durvalumab or pembrolizumab to cisplatin–gemcitabine improves overall survival (OS), but validated biomarkers of benefit remain limited. Immune-mediated adverse ev...

Comparison of Diagnostic Performance of Whole-Body 360° CZT Bone SPECT/CT and Planar Bone Scintigraphy in Detecting Bone Metastasis in Small Cell Lung Cancer

Background/Objectives: We aimed to compare the diagnostic performances of planar bone scintigraphy and whole-body 360° cadmium–zinc–telluride (CZT) bone single-photon emission computed tomography/computed tomography (SPECT/CT) in detecting bone metastasis in patients with small c...

P1.192. Prospective Observational Study of Intraoperative Right Gastroepiploic Artery Flow and Anastomosis Level (Distance From Upper Incisors) in Ivor-Lewis Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Anastomotic leakage after esophagectomy is strongly associated with gastric conduit ischemia. Although indocyanine green fluorescence imaging is widely used, quantitative perfusion assessment rem...

Claims-defined hepatic steatosis compatible with MASLD and reproductive outcomes after the first observed embryo transfer: a Korean nationwide cohort study

Metabolic dysfunction–associated steatotic liver disease (MASLD) is increasingly prevalent among women of reproductive age; however, its association with reproductive outcomes after in vitro fertilization (IVF) remains insufficiently characterized in population-level data. We eva...

Hyaluronic Acid Hydrogel Incorporating Dexpanthenol-Engineered Extracellular Vesicles for Accelerated Wound Closure and Mitigated Secondary Infection Risk

Background: Loss of epithelial integrity leaves the wound bed open to opportunistic bacterial colonization, and the risk of secondary infection persists for as long as the defect remains unclosed. Wound dressings must therefore provide an immediate external barrier while accelera...

Harnessing Gradient Topography and Dual‐Mode Bioactive Delivery via Bone‐Adhesive Exosome Mimetics for Rotator Cuff Tendon–Bone Interface Repair

ABSTRACT Rotator cuff repair frequently fails because the native enthesis relies on a continuous structural and compositional transition from tendon to bone. Here, we present an enthesis‐mimetic, dual‐gradient scaffold that couples a continuous random‐to‐aligned fiber orientation...