CHA University

Prioritizing Emergency Medical Conditions for Health Policy Using a Stepwise Treatable-Death Framework: A Nationwide Analysis in Korea, 2018–2022

Background/Objectives: Limited emergency-care resources require priorities based not only on mortality rates or death counts but also on the potential mortality reduction under explicit targets. We applied the age- and sex-standardized domestic short- and mid-term components of a...

Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial

PURPOSE: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovasc...

Health literacy and metabolic syndrome in Korean adults: a nationwide cross-sectional analysis of KNHANES 2023–2024

Health literacy (HL) is a social determinant of health, yet its independent, population-level association with metabolic syndrome (MetS) remains unclear, particularly in Asian populations. Using data from the first Korea National Health and Nutrition Examination Survey cycles to...

Exercise, Glucose and Lactate Metabolism in Mild Cognitive Impairment: A Narrative Review

Mild cognitive impairment (MCI) is associated with cerebral glucose hypometabolism and an increased risk of progression to Alzheimer’s disease (AD). Altered lactate metabolism may represent an additional component of this metabolic vulnerability. We propose the Dual-Fuel Hypothes...

Comparison of Neurophysiological Characteristics Using Heart Rate Variability Between Patients With Korean Hwa-byung and Healthy Individuals

Objective Hwa-byung (HB) is a syndrome associated with stressful events within Korea’s social and cultural contexts. The clinical symptoms of HB may be associated with autonomic imbalance. This study investigated the neurophysiological characteristics of HB by comparing heart rat...

Intercellular Transfer of CD155 Mediated by Melanoma Extracellular Vesicles Downregulates DNAM-1 Expression on NK Cells

Melanoma is a highly immunogenic cancer, and immunotherapy is the first-line treatment for patients with advanced disease. However, CD155 overexpression in melanoma has been associated with resistance to immunotherapy. Whether CD155 can be transferred from tumour cells via extrac...

Personalized deep learning for short-term forecasting of impending atrial fibrillation from continuous wearable ECG signals

Abstract Continuous wearable electrocardiogram (ECG) monitoring is increasingly used for ambulatory arrhythmia surveillance, yet forecasting impending atrial fibrillation (AF) remains challenging because of inter-patient ECG variability. We investigated whether personalizing a gl...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Risk of peripheral artery disease following ankylosing spondylitis, 2012–2023: a nationwide cohort study in South Korea

OBJECTIVE: Ankylosing spondylitis (AS) is a chronic inflammatory disease linked to systemic vascular complications. Evidence regarding the association between AS and peripheral artery disease (PAD) remains limited. We investigated whether patients with AS have an increased risk o...

Extracellular vesicles derived from the lactic acid bacterium Enterococcus rotai suppress melanogenesis by modulating the cAMP-MITF pathway

Enterococcus rotai CMTB-CA6-derived extracellular vesicles (CA6-ErEVs), isolated from a Centella asiatica -associated lactic acid bacterium, were investigated for their potential to modulate oxidative stress, inflammation, and melanogenesis in skin cells. CA6-ErEVs were purified...

Balancing Ubiquitination and Deubiquitination in Apoptotic Protein Stability and Cancer Cell Survival

Programmed cell death is essential for maintaining cellular homeostasis, and its evasion is a defining hallmark of cancer. The threshold for apoptosis is largely determined by the stability of pro- and anti-apoptotic proteins, which is tightly regulated by the ubiquitin–proteasom...

Repeated Short-Term Intratracheal Exposure to Urban Particulate Matter Has No Apparent Adverse Effects on Female Reproductive Outcomes in Mice

Urban particulate matter (UPM) is a major environmental pollutant known to induce systemic inflammation. While its respiratory toxicity is well-documented, the potential vulnerability of the female reproductive system to inhaled UPM remains a critical concern. In this study, we e...

Claims-defined hepatic steatosis compatible with MASLD and reproductive outcomes after the first observed embryo transfer: a Korean nationwide cohort study

Metabolic dysfunction–associated steatotic liver disease (MASLD) is increasingly prevalent among women of reproductive age; however, its association with reproductive outcomes after in vitro fertilization (IVF) remains insufficiently characterized in population-level data. We eva...

Hyaluronic Acid Hydrogel Incorporating Dexpanthenol-Engineered Extracellular Vesicles for Accelerated Wound Closure and Mitigated Secondary Infection Risk

Background: Loss of epithelial integrity leaves the wound bed open to opportunistic bacterial colonization, and the risk of secondary infection persists for as long as the defect remains unclosed. Wound dressings must therefore provide an immediate external barrier while accelera...

Prenatal PM2.5 exposure drives epigenetic reprogramming of fetal macrophages linked to atopic dermatitis

Abstract Prenatal environmental exposures are increasingly recognized as contributors to atopic dermatitis (AD), yet the underlying mechanisms remain unclear. Fine particulate matter (PM 2.5 ), a complex mixture of airborne pollutants, has been associated with elevated risk of al...

Harnessing Gradient Topography and Dual‐Mode Bioactive Delivery via Bone‐Adhesive Exosome Mimetics for Rotator Cuff Tendon–Bone Interface Repair

ABSTRACT Rotator cuff repair frequently fails because the native enthesis relies on a continuous structural and compositional transition from tendon to bone. Here, we present an enthesis‐mimetic, dual‐gradient scaffold that couples a continuous random‐to‐aligned fiber orientation...