Centro Universitário Claretiano

Paiva's Adaptive Window Heuristic Applied to the PRNP Variant Scanner: Rapid Computational Screening of Pathogenic PRNP Variants by Rabin-Karp Algorithm with Polynomial Hash over a Prime Field.

Human prion diseases, particularly Creutzfeldt-Jakob Disease (CJD), are characterized by rapid progression and a narrow therapeutic window. A documented mean diagnostic delay of 7.8 months - exceeding the median survival of 4 to 6 months - compromises patient eligibility for acti...