Centro San Giovanni di Dio Fatebenefratelli

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Beyond Genotype: Integrating Phenoconversion into Pharmacogenetic Decision-Making in Psychiatry

Interindividual variability in psychotropic drug response contributes to treatment failure, adverse drug reactions, and repeated medication adjustments. Pharmacogenetics supports precision prescribing by identifying genetic variants associated with drug metabolism, efficacy, and...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

Identifying activity patterns from different actigraphy devices in people with schizophrenia spectrum disorders: a comparative study

Abstract Actigraphy is a reliable and non-invasive method for assessing motor activity and how disease affects the daily activity of patients. Machine learning models applied to actigraphy data have been used to identify activity patterns in patients suffering from either major d...

Emotion dysregulation in adolescents: comparing community and clinical samples and their association with mental health and risk behaviors

Abstract Background Emotion dysregulation (ED) is a multidimensional construct associated with mental health disorders, however, its distribution and clinical significance in the adolescent general population remain underexplored. This study aimed to investigate the prevalence an...

Functional Activity of TDP-43: A Direct Biomarker for ALS

TDP-43 dysfunction is a defining feature of amyotrophic lateral sclerosis (ALS), yet no biofluid biomarker directly measures its functional activity. We developed a serum-based homogeneous time-resolved FRET (hTR-FRET) assay that quantifies TDP-43 RNA binding activity using synth...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...